HSH2D and RBP7

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		HSH2D	RBP7
Description		hematopoietic SH2 domain containing	retinol binding protein 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Retinoid Binding Fatty Acid Binding Protein Binding Lipid Binding Retinal Binding Retinol Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Signal Transduction T Cell Activation Negative Regulation Of Mitochondrial Depolarization	Fatty Acid Transport
Pathways
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		21 interacting genes: AR CNMD CRK EGFR ERBB2 ERBB3 ERBB4 FES GAB1 KIT LDHAL6B MET MPP3 OLIG1 PIK3R3 PINK1 PLPP6 RBP7 TNK2 TSC1 TSG101	5 interacting genes: APPL2 DAPP1 DOK4 HSH2D NCKIPSD
Entrez ID		84941	116362
HPRD ID		12219	16355
Ensembl ID		ENSG00000196684	ENSG00000162444
Uniprot IDs		Q96JZ2	Q96R05
PDB IDs		2CS0	1LPJ 6AT8 6E6K
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Developmental Process Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility ERBB3:ERBB2 Complex Positive Regulation Of Phosphate Metabolic Process Animal Organ Development Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Protein Modification Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Phosphorylation Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Regulation Of Cell Migration Positive Regulation Of Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Population Proliferation	Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Phagosome Membrane Cold Acclimation Photoreceptor Distal Connecting Cilium
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