HSH2D and LDHAL6B

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		HSH2D	LDHAL6B
Description		hematopoietic SH2 domain containing	lactate dehydrogenase A like 6B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Oxidoreductase Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Catalytic Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Signal Transduction T Cell Activation Negative Regulation Of Mitochondrial Depolarization	Lactate Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process
Pathways			Pyruvate metabolism
Drugs			NADH
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		21 interacting genes: AR CNMD CRK EGFR ERBB2 ERBB3 ERBB4 FES GAB1 KIT LDHAL6B MET MPP3 OLIG1 PIK3R3 PINK1 PLPP6 RBP7 TNK2 TSC1 TSG101	6 interacting genes: APPL2 HSH2D PRMT5 PRMT6 SOCS4 SUV39H1
Entrez ID		84941	92483
HPRD ID		12219	13981
Ensembl ID		ENSG00000196684	ENSG00000171989
Uniprot IDs		Q96JZ2	A0A140VJM9 Q9BYZ2
PDB IDs		2CS0
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Developmental Process Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility ERBB3:ERBB2 Complex Positive Regulation Of Phosphate Metabolic Process Animal Organ Development Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Protein Modification Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Phosphorylation Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Regulation Of Cell Migration Positive Regulation Of Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Population Proliferation	Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methyltransferase Activity Methylation Negative Regulation Of Metabolic Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Peptidyl-arginine N-methylation Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Histone H3R2 Methyltransferase Activity Positive Regulation Of Macropinocytosis ENoSc Complex Negative Regulation Of Macromolecule Metabolic Process Circadian Rhythm Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Early Phagosome Membrane Cold Acclimation Regulation Of Multicellular Organismal Development Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling RDNA Heterochromatin Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation Protein Retention In Golgi Apparatus Protein-arginine Omega-N Monomethyltransferase Activity Macropinosome Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway RDNA Heterochromatin Formation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Positive Regulation Of Pinocytosis Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Chromatin Organization Regulation Of Cell Development Adiponectin-activated Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Histone H3K9 Methyltransferase Activity Golgi Ribbon Formation Endothelial Cell Activation Diet Induced Thermogenesis Nuclear Lamina
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