MMP17 and LRP1

Number of citations of the paper that reports this interaction (PMID 14645246)
21

Data Source:
HPRD (in vitro)

		MMP17	LRP1
Gene Name		matrix metallopeptidase 17 (membrane-inserted)	low density lipoprotein receptor-related protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Integral Component Of Plasma Membrane Anchored Component Of Membrane	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding
	Biological Process	Proteolysis Positive Regulation Of Catalytic Activity	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Migraine ( 22683712)	Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		3 interactors: LRP1 MMP2 TNF	63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		4326	4035
HPRD ID		03793	00138
Ensembl ID		ENSG00000198598	ENSG00000123384
Uniprot IDs		Q8IWC3 Q9ULZ9	Q07954 Q59FG2
PDB IDs			1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Stimulus Response To Amino Acid Response To Abiotic Stimulus Negative Regulation Of Branching Involved In Lung Morphogenesis Beta-amyloid Clearance Negative Regulation Of L-glutamate Transport Cellular Response To Acid Chemical Detection Of Abiotic Stimulus Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Regulation Of Neuron Apoptotic Process Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Neuron Death Response To Hypoxia Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Response To External Stimulus Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Transport Necroptotic Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Receptor Biosynthetic Process Transformed Cell Apoptotic Process Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Podosome Assembly Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NFAT Protein Import Into Nucleus Blood Vessel Morphogenesis Activation Of MAPKKK Activity Negative Regulation Of Alkaline Phosphatase Activity Cellular Response To Nicotine Intramembranous Ossification Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Action Potential Cellular Response To Organonitrogen Compound Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Fever Generation Bone Trabecula Formation	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell
Tagcloud ?		ablation alteration chip demethylases depletion duplications fundamental h3k4 h3k4me3 hallmark herein hsetd1a link mark mechanistic metalloproteinases metastasis methyltransferase methyltransferases mmp12 mmp13 mmp2 mmp9 mmps nevertheless nude reveals setd1a supporting	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Difference) ?		ablation alteration chip demethylases depletion duplications fundamental h3k4 h3k4me3 hallmark herein hsetd1a link mark mechanistic metalloproteinases metastasis methyltransferase methyltransferases mmp12 mmp13 mmp2 mmp9 mmps nevertheless nude reveals setd1a supporting	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Intersection) ?