MMP17 and TNF

Number of citations of the paper that reports this interaction (PMID 10799478)
24

Data Source:
HPRD (in vitro)

		MMP17	TNF
Gene Name		matrix metallopeptidase 17 (membrane-inserted)	tumor necrosis factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Integral Component Of Plasma Membrane Anchored Component Of Membrane	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding	Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Proteolysis Positive Regulation Of Catalytic Activity	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Response To Hypoxia Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of L-glutamate Transport Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Glucose Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Inflammatory Response Humoral Immune Response JNK Cascade Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Virus Response To Salt Stress Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Lipid Storage Response To Activity Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Positive Regulation Of Protein Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Viral Genome Replication Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Action Potential Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	TNF signaling Death Receptor Signalling Transcriptional regulation of white adipocyte differentiation Programmed Cell Death Extrinsic Pathway
Drugs			Etanercept Adalimumab Infliximab Chloroquine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone golimumab Certolizumab pegol Pomalidomide
Diseases
GWAS		Migraine ( 22683712)	AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		3 interactors: LRP1 MMP2 TNF	21 interactors: ADAM17 ADAM9 BGN CSF1 DCN FYN IFNG LYN MMP17 NFKBIA PDIK1L POU2F1 PRTN3 RC3H1 RIPK1 TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF2 YWHAQ
Entrez ID		4326	7124
HPRD ID		03793	01855
Ensembl ID		ENSG00000198598	ENSG00000232810
Uniprot IDs		Q8IWC3 Q9ULZ9	P01375 Q5STB3
PDB IDs			1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Stimulus Response To Amino Acid Response To Abiotic Stimulus Negative Regulation Of Branching Involved In Lung Morphogenesis Beta-amyloid Clearance Negative Regulation Of L-glutamate Transport Cellular Response To Acid Chemical Detection Of Abiotic Stimulus Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Regulation Of Neuron Apoptotic Process Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Neuron Death Response To Hypoxia Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Response To External Stimulus Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Transport Necroptotic Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Receptor Biosynthetic Process Transformed Cell Apoptotic Process Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Podosome Assembly Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NFAT Protein Import Into Nucleus Blood Vessel Morphogenesis Activation Of MAPKKK Activity Negative Regulation Of Alkaline Phosphatase Activity Cellular Response To Nicotine Intramembranous Ossification Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Action Potential Cellular Response To Organonitrogen Compound Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Fever Generation Bone Trabecula Formation	Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Immune Response Immune System Process Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Intracellular Signal Transduction Response To Other Organism Programmed Cell Death Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Cell Death Death Cellular Response To Organic Substance Regulation Of Apoptotic Process Regulation Of Cytokine Production Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Lipid Regulation Of Signaling Response To Organic Substance Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Cellular Response To Lipid Defense Response Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation Leukocyte Activation Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Innate Immune Response Leukocyte Differentiation Positive Regulation Of Phosphorylation
Tagcloud ?		ablation alteration chip demethylases depletion duplications fundamental h3k4 h3k4me3 hallmark herein hsetd1a link mark mechanistic metalloproteinases metastasis methyltransferase methyltransferases mmp12 mmp13 mmp2 mmp9 mmps nevertheless nude reveals setd1a supporting	aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately
Tagcloud (Difference) ?		ablation alteration chip demethylases depletion duplications fundamental h3k4 h3k4me3 hallmark herein hsetd1a link mark mechanistic metalloproteinases metastasis methyltransferase methyltransferases mmp12 mmp13 mmp2 mmp9 mmps nevertheless nude reveals setd1a supporting	aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately
Tagcloud (Intersection) ?