MMP14 and MMP2

Number of citations of the paper that reports this interaction (PMID 8663332)
79

Data Source:
HPRD (in vitro)

		MMP14	MMP2
Gene Name		matrix metallopeptidase 14 (membrane-inserted)	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs			Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		4323	4313
HPRD ID		02856	00386
Ensembl ID		ENSG00000157227	ENSG00000087245
Uniprot IDs		P50281	P08253
PDB IDs		1BQQ 1BUV 3C7X 3MA2	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?		5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?		5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?		metalloproteinase