MMP14 and PLLP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MMP14	PLLP
Description		matrix metallopeptidase 14	plasmolipin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Myelin Sheath Compact Myelin Membrane Raft
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Cell Migration Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Bone Development Cellular Response To Genistein Craniofacial Suture Morphogenesis GDF15-GFRAL Signaling Pathway Negative Regulation Of GDF15-GFRAL Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Monoatomic Ion Transport Regulation Of Endocytosis Myelin Assembly Myelination Regulation Of Transcytosis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Marimastat
Diseases
GWAS		Appendicular lean mass ( 33097823) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 28869591 30598549) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Sleep duration ( 23728906) Systemic lupus erythematosus ( 28714469)
Interacting Genes		44 interacting genes: ACAN ACE2 ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CCN2 CCN5 CLDN1 CORO1C CXCL8 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SLPI SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 TNF TNFRSF21 ZUP1	57 interacting genes: AQP6 BCL2L13 BIK CCR2 CD164L2 CLDN14 CLEC12B CLEC2D CRB3 CREB3 CYB5R3 CYSRT1 DRD2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FKBP7 FNDC9 FRS3 GOLT1A GPR35 GPX8 GRN HOXA1 HTR2B KCNJ6 KRT34 KRTAP10-1 KRTAP9-2 LHFPL5 LMNA MC4R MFF MMP14 MS4A12 OPRL1 PACC1 PGRMC2 PTAFR RNF122 SAR1A SLC10A6 SLC35H1 STING1 SYPL2 TIGIT TMEM14B TMEM167B TMEM174 TMPPE TMPRSS2 TNFSF14 TRIM59 VMA21 ZDHHC15
Entrez ID		4323	51090
HPRD ID		02856	11854
Ensembl ID		ENSG00000157227	ENSG00000102934
Uniprot IDs		P50281	Q9Y342
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Extracellular Region Metalloendopeptidase Inhibitor Activity Regulation Of Membrane Protein Ectodomain Proteolysis Enzyme Inhibitor Activity Regulation Of Entry Of Bacterium Into Host Cell Symbiont Entry Into Host Cell Response To Amyloid-beta Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cell Motility Regulation Of Locomotion Biological Process Involved In Interaction With Host Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Endopeptidase Activity Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Proteolysis Regulation Of Transcytosis Extracellular Matrix Disassembly Peptidase Inhibitor Activity Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Endocytosis Membrane Raft Positive Regulation Of Locomotion Collagen Binding Collagen Metabolic Process Regulation Of Viral Process Leukocyte Migration Regulation Of Bicellular Tight Junction Assembly Apoptotic Cell Clearance Negative Regulation Of Proteolysis Viral Translation Viral Life Cycle Regulation Of Protein Catabolic Process Serine-type Endopeptidase Activity Regulation Of Multicellular Organismal Process Humoral Immune Response Heparin Binding Cell Motility Regulation Of Cell Junction Assembly Virus Receptor Activity Extracellular Matrix Binding Response To Cytokine Response To Peptide Receptor-mediated Endocytosis	Membrane Endoplasmic Reticulum PH-gated Chloride Channel Activity Protein Binding Regulation Of Behavior Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
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