Wiki-Pi
About
Search
People
Updates
Search
MMP14 and RRAD
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
MMP14
RRAD
Description
matrix metallopeptidase 14
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Cytosol
Plasma Membrane
Membrane
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Integrin Binding
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Metalloaminopeptidase Activity
Nucleotide Binding
GTPase Activity
Calcium Channel Regulator Activity
Protein Binding
Calmodulin Binding
GTP Binding
Biological Process
Skeletal System Development
Ossification
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Anatomical Structure Morphogenesis
Response To Hormone
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Cell Migration
Protein Processing
Extracellular Matrix Disassembly
Protein Catabolic Process
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Bone Development
Cellular Response To Genistein
Craniofacial Suture Morphogenesis
GDF15-GFRAL Signaling Pathway
Negative Regulation Of GDF15-GFRAL Signaling Pathway
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Small GTPase-mediated Signal Transduction
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
TGFBR3 PTM regulation
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
NGF-stimulated transcription
Drugs
Marimastat
Diseases
GWAS
Appendicular lean mass (
33097823
)
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
28869591
30598549
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
44 interacting genes:
ACAN
ACE2
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CCN2
CCN5
CLDN1
CORO1C
CXCL8
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SLPI
SPOCK1
SPOCK3
STOM
TGM2
TIMP2
TIMP3
TIMP4
TMEM31
TNF
TNFRSF21
ZUP1
15 interacting genes:
CALM1
CAMK2G
CCDC141
CSNK2A1
CSNK2B
EEA1
EGFR
MMP14
NME1
PRKACA
PRKCA
PRKCB
STAT3
TPM2
YWHAZ
Entrez ID
4323
6236
HPRD ID
02856
01536
Ensembl ID
ENSG00000157227
ENSG00000166592
Uniprot IDs
P50281
P55042
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
2DPX
2GJS
3Q72
3Q7P
3Q7Q
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Space
Extracellular Region
Metalloendopeptidase Inhibitor Activity
Regulation Of Membrane Protein Ectodomain Proteolysis
Enzyme Inhibitor Activity
Regulation Of Entry Of Bacterium Into Host Cell
Symbiont Entry Into Host Cell
Response To Amyloid-beta
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Cell Motility
Regulation Of Locomotion
Biological Process Involved In Interaction With Host
Extracellular Matrix Organization
Extracellular Structure Organization
Collagen Catabolic Process
Endopeptidase Activity
Regulation Of Cell Migration
Regulation Of Cell Adhesion
Regulation Of Proteolysis
Regulation Of Transcytosis
Extracellular Matrix Disassembly
Peptidase Inhibitor Activity
Positive Regulation Of Cell Migration
Cell Migration
Positive Regulation Of Cell Motility
Endocytosis
Membrane Raft
Positive Regulation Of Locomotion
Collagen Binding
Collagen Metabolic Process
Regulation Of Viral Process
Leukocyte Migration
Regulation Of Bicellular Tight Junction Assembly
Apoptotic Cell Clearance
Negative Regulation Of Proteolysis
Viral Translation
Viral Life Cycle
Regulation Of Protein Catabolic Process
Serine-type Endopeptidase Activity
Regulation Of Multicellular Organismal Process
Humoral Immune Response
Heparin Binding
Cell Motility
Regulation Of Cell Junction Assembly
Virus Receptor Activity
Extracellular Matrix Binding
Response To Cytokine
Response To Peptide
Receptor-mediated Endocytosis
Kinase Activity
Protein Serine/threonine Kinase Activity
Phosphorylation
Histone H3T6 Kinase Activity
Cytosol
Protein Kinase CK2 Complex
Symbiont-mediated Disruption Of Host Cell PML Body
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Kinase C Signaling
Regulation Of Protein Localization
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Protein Phosphorylation
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Epithelial Cell Proliferation
Cytoplasm
Regulation Of Signal Transduction
Mitotic Nuclear Membrane Disassembly
Intracellular Signal Transduction
Modulation Of Chemical Synaptic Transmission
Establishment Of Protein Localization
Identical Protein Binding
Interleukin-2-mediated Signaling Pathway
Intracellular Signaling Cassette
Regulation Of Muscle System Process
Positive Regulation Of Insulin Secretion
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Phosphate-containing Compound Metabolic Process
Protein Phosphatase Binding
Nuclear Membrane Disassembly
ATP Binding
Regulation Of Biological Quality
Membrane Disassembly
Negative Regulation Of Signal Transduction
Diacylglycerol-dependent Serine/threonine Kinase Activity
Signal Transduction
Calyx Of Held
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Response To Estradiol
Negative Regulation Of Glycolytic Process
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Peptide Secretion
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?