MMP14 and CCL7

Number of citations of the paper that reports this interaction (PubMedID 10947989)
0

Data Source:
HPRD (in vitro, in vivo)

		MMP14	CCL7
Description		matrix metallopeptidase 14	C-C motif chemokine ligand 7
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Cell Migration Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Bone Development Cellular Response To Genistein Craniofacial Suture Morphogenesis GDF15-GFRAL Signaling Pathway Negative Regulation Of GDF15-GFRAL Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Monocyte Chemotaxis Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Canonical NF-kappaB Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Chemokine receptors bind chemokines
Drugs		Marimastat
Diseases
GWAS		Appendicular lean mass ( 33097823) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 28869591 30598549) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood protein levels ( 30072576) Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908)
Interacting Genes		44 interacting genes: ACAN ACE2 ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CCN2 CCN5 CLDN1 CORO1C CXCL8 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SLPI SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 TNF TNFRSF21 ZUP1	18 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 CXCL6 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1 UBQLN2 XCL2
Entrez ID		4323	6354
HPRD ID		02856	01150
Ensembl ID		ENSG00000157227	ENSG00000108688
Uniprot IDs		P50281	P80098
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1	1BO0 1NCV 4ZKC 7S58 7S59 7SCU 8FJ3 8FK6 8FK8 8JPS
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Extracellular Region Metalloendopeptidase Inhibitor Activity Regulation Of Membrane Protein Ectodomain Proteolysis Enzyme Inhibitor Activity Regulation Of Entry Of Bacterium Into Host Cell Symbiont Entry Into Host Cell Response To Amyloid-beta Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cell Motility Regulation Of Locomotion Biological Process Involved In Interaction With Host Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Endopeptidase Activity Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Proteolysis Regulation Of Transcytosis Extracellular Matrix Disassembly Peptidase Inhibitor Activity Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Endocytosis Membrane Raft Positive Regulation Of Locomotion Collagen Binding Collagen Metabolic Process Regulation Of Viral Process Leukocyte Migration Regulation Of Bicellular Tight Junction Assembly Apoptotic Cell Clearance Negative Regulation Of Proteolysis Viral Translation Viral Life Cycle Regulation Of Protein Catabolic Process Serine-type Endopeptidase Activity Regulation Of Multicellular Organismal Process Humoral Immune Response Heparin Binding Cell Motility Regulation Of Cell Junction Assembly Virus Receptor Activity Extracellular Matrix Binding Response To Cytokine Response To Peptide Receptor-mediated Endocytosis	Chemokine-mediated Signaling Pathway C-C Chemokine Binding Chemokine Receptor Activity C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Cell Surface Receptor Signaling Pathway Calcium-mediated Signaling Endopeptidase Activity Metalloendopeptidase Activity Cell Motility G Protein-coupled Receptor Signaling Pathway Cellular Response To UV-A G Protein-coupled Receptor Activity Metallopeptidase Activity Response To UV-A Serine-type Endopeptidase Activity Chemokine (C-C Motif) Ligand 5 Binding Inflammatory Response Immune System Process External Side Of Plasma Membrane Immune Response Response To Stress Extracellular Structure Organization Extracellular Matrix Organization Leukocyte Chemotaxis Chemokine Binding Intracellular Signaling Cassette Response To Amyloid-beta Defense Response Extracellular Matrix Leukocyte Migration Peptidase Activity Cellular Response To UV Signal Transduction Dendritic Cell Chemotaxis Positive Regulation Of ERAD Pathway Mononuclear Cell Migration Proteolysis Cellular Response To Light Stimulus Plasma Membrane Response To Cytokine Dendritic Cell Migration
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