MMP14 and CCN2

Number of citations of the paper that reports this interaction (PubMedID 15255181)
0

Data Source:
BioGRID (enzymatic study)

		MMP14	CCN2
Description		matrix metallopeptidase 14	cellular communication network factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Extracellular Matrix Cell Periphery
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Cell Migration Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Bone Development Cellular Response To Genistein Craniofacial Suture Morphogenesis GDF15-GFRAL Signaling Pathway Negative Regulation Of GDF15-GFRAL Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Cartilage Condensation Ossification Angiogenesis Osteoblast Differentiation Tissue Homeostasis Chondrocyte Differentiation Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Negative Regulation Of Gene Expression Cell Migration Lung Development Regulation Of Chondrocyte Differentiation Chondrocyte Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Regulation Of Developmental Process Positive Regulation Of Stress Fiber Assembly Connective Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs		Marimastat
Diseases
GWAS		Appendicular lean mass ( 33097823) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 28869591 30598549) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		44 interacting genes: ACAN ACE2 ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CCN2 CCN5 CLDN1 CORO1C CXCL8 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SLPI SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 TNF TNFRSF21 ZUP1	15 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LIMS1 LRP1 MMP14 MTDH RSPH1 TGFB1 TGFB2 TGFB3 VEGFA
Entrez ID		4323	1490
HPRD ID		02856	00412
Ensembl ID		ENSG00000157227	ENSG00000118523
Uniprot IDs		P50281	P29279 Q5M8T4
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Extracellular Region Metalloendopeptidase Inhibitor Activity Regulation Of Membrane Protein Ectodomain Proteolysis Enzyme Inhibitor Activity Regulation Of Entry Of Bacterium Into Host Cell Symbiont Entry Into Host Cell Response To Amyloid-beta Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cell Motility Regulation Of Locomotion Biological Process Involved In Interaction With Host Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Endopeptidase Activity Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Proteolysis Regulation Of Transcytosis Extracellular Matrix Disassembly Peptidase Inhibitor Activity Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Endocytosis Membrane Raft Positive Regulation Of Locomotion Collagen Binding Collagen Metabolic Process Regulation Of Viral Process Leukocyte Migration Regulation Of Bicellular Tight Junction Assembly Apoptotic Cell Clearance Negative Regulation Of Proteolysis Viral Translation Viral Life Cycle Regulation Of Protein Catabolic Process Serine-type Endopeptidase Activity Regulation Of Multicellular Organismal Process Humoral Immune Response Heparin Binding Cell Motility Regulation Of Cell Junction Assembly Virus Receptor Activity Extracellular Matrix Binding Response To Cytokine Response To Peptide Receptor-mediated Endocytosis	Extracellular Matrix Regulation Of SMAD Protein Signal Transduction Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Localization Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Response To Hypoxia Negative Regulation Of Macrophage Cytokine Production Regulation Of Cell Population Proliferation Response To Decreased Oxygen Levels Growth Factor Activity Response To Growth Factor Positive Regulation Of Cell Differentiation Response To Oxygen Levels Transforming Growth Factor Beta Receptor Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Population Proliferation Cell-cell Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Uterine Wall Breakdown Extracellular Space Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Locomotion Positive Regulation Of Cell Division Positive Regulation Of Metabolic Process Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Localization Cell Junction Organization Gland Morphogenesis Face Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization To Plasma Membrane
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