COL18A1 and KDR

Number of citations of the paper that reports this interaction (PMID 12029087)
50

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		COL18A1	KDR
Gene Name		collagen, type XVIII, alpha 1	kinase insert domain receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Nucleus Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Membrane Raft Sorting Endosome
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Hsp90 Protein Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Ovarian Follicle Development Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mesenchymal Cell Proliferation Endothelium Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Extracellular Matrix Organization Positive Regulation Of Cell Migration Embryonic Hemopoiesis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of MAPK Cascade Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Cell Maturation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Focal Adhesion Assembly Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Collagen formation Laminin interactions Collagen degradation Activation of Matrix Metalloproteinases Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	VEGF binds to VEGFR leading to receptor dimerization EPHA-mediated growth cone collapse VEGF ligand-receptor interactions Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF EPH-Ephrin signaling Neurophilin interactions with VEGF and VEGFR Integrin cell surface interactions VEGFA-VEGFR2 Pathway
Drugs			Sorafenib Sunitinib N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA Pazopanib Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib
Diseases
GWAS		Hippocampal atrophy ( 22745009)
Protein-Protein Interactions		8 interactors: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2	49 interactors: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 FBXO25 FBXW11 FIGF FLT1 FLT4 FRS2 FYN GNA11 GNAQ GRB10 GRB2 HSP90AA1 IQGAP1 ITGB3 NCK1 NRP1 P2RY2 PLCG1 PLCG2 PTPN11 PTPN6 RASA1 SH2D2A SHB SHC1 SHC2 SRC STAT1 SYNGAP1 TIMP3 UBC VEGFA VEGFC YES1
Entrez ID		80781	3791
HPRD ID		00382	01867
Ensembl ID		ENSG00000182871	ENSG00000128052
Uniprot IDs		D3DSM4 D3DSM5 P39060	P35968
PDB IDs		1BNL 3HON 3HSH	1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Catabolic Process Angiogenesis Endoderm Formation Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Positive Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Axon Guidance Phototransduction, Visible Light Collagen Metabolic Process Blood Vessel Morphogenesis Retinoid Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Diterpenoid Metabolic Process Multicellular Organismal Metabolic Process Detection Of Visible Light Phototransduction Extracellular Matrix Disassembly Locomotion Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Blood Vessel Development Proteoglycan Metabolic Process Detection Of Light Stimulus Axonogenesis Vasculature Development Heparan Sulfate Proteoglycan Catabolic Process Macrophage Apoptotic Process Axon Development Isoprenoid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Proteoglycan Catabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Body Fluid Levels Response To Growth Factor Anatomical Structure Morphogenesis Response To Wounding Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Platelet Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process System Development Response To Organic Substance Cardiovascular System Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Development Cell Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Leukocyte Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Blood Vessel Development Cellular Response To Peptide Positive Regulation Of Metabolic Process Angiogenesis
Tagcloud ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Difference) ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Intersection) ?