COL18A1 and GPC1

Number of citations of the paper that reports this interaction (PMID 11336704)
42

Data Source:
HPRD (in vivo, in vitro)

		COL18A1	GPC1
Gene Name		collagen, type XVIII, alpha 1	glypican 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Endosome Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Metal Ion Binding	Copper Ion Binding Fibroblast Growth Factor Binding Laminin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Pathogenesis Schwann Cell Differentiation Heparan Sulfate Proteoglycan Catabolic Process Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Collagen formation Laminin interactions Collagen degradation Activation of Matrix Metalloproteinases Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Inactivation of Cdc42 and Rac Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA Activation of Rac MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Role of Abl in Robo-Slit signaling Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates Signaling by Robo receptor HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009)	Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		8 interactors: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2	5 interactors: APP COL18A1 SLIT1 SLIT2 VEGFA
Entrez ID		80781	2817
HPRD ID		00382	02671
Ensembl ID		ENSG00000182871	ENSG00000063660
Uniprot IDs		D3DSM4 D3DSM5 P39060	P35052
PDB IDs		1BNL 3HON 3HSH	4ACR 4AD7
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Catabolic Process Angiogenesis Endoderm Formation Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Positive Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Axon Guidance Phototransduction, Visible Light Collagen Metabolic Process Blood Vessel Morphogenesis Retinoid Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Diterpenoid Metabolic Process Multicellular Organismal Metabolic Process Detection Of Visible Light Phototransduction Extracellular Matrix Disassembly Locomotion Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Blood Vessel Development Proteoglycan Metabolic Process Detection Of Light Stimulus Axonogenesis Vasculature Development Heparan Sulfate Proteoglycan Catabolic Process Macrophage Apoptotic Process Axon Development Isoprenoid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Proteoglycan Catabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation	Cell Morphogenesis Involved In Differentiation Regulation Of Developmental Growth Regulation Of Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Regulation Of Axon Extension Dorsal/ventral Axon Guidance Axon Guidance Developmental Cell Growth Growth Axonogenesis Regulation Of Neuron Differentiation Axon Extension Involved In Axon Guidance Regulation Of Cell Size Axon Development Regulation Of Chemotaxis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Developmental Growth Involved In Morphogenesis Regulation Of Growth Cell Growth Neuron Projection Morphogenesis Cell Development Regulation Of Axonogenesis Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Behavior Negative Regulation Of Neuron Differentiation Negative Chemotaxis Neuron Projection Development Cell Migration Involved In Sprouting Angiogenesis Retinal Ganglion Cell Axon Guidance Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Negative Regulation Of Axon Extension Anatomical Structure Morphogenesis Negative Regulation Of Chemotaxis Neuron Development Regulation Of Vascular Permeability Organ Morphogenesis Developmental Growth Negative Regulation Of Neurogenesis Blood Vessel Endothelial Cell Migration Motor Neuron Axon Guidance Neuron Differentiation Regulation Of Cellular Component Size Angiogenesis Negative Regulation Of Cell Development
Tagcloud ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?