COL18A1 and GPC4

Number of citations of the paper that reports this interaction (PMID 11336704)
42

Data Source:
HPRD (in vitro)

		COL18A1	GPC4
Gene Name		collagen, type XVIII, alpha 1	glypican 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Nucleus Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Metal Ion Binding	Heparan Sulfate Proteoglycan Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Cell Proliferation Pathogenesis Anatomical Structure Morphogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		Collagen formation Laminin interactions Collagen degradation Activation of Matrix Metalloproteinases Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009)
Protein-Protein Interactions		8 interactors: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2	3 interactors: ACP5 COL18A1 FGF2
Entrez ID		80781	2239
HPRD ID		00382	02160
Ensembl ID		ENSG00000182871
Uniprot IDs		D3DSM4 D3DSM5 P39060	B4E2C0 O75487
PDB IDs		1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Catabolic Process Angiogenesis Endoderm Formation Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Positive Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Axon Guidance Phototransduction, Visible Light Collagen Metabolic Process Blood Vessel Morphogenesis Retinoid Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Diterpenoid Metabolic Process Multicellular Organismal Metabolic Process Detection Of Visible Light Phototransduction Extracellular Matrix Disassembly Locomotion Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Blood Vessel Development Proteoglycan Metabolic Process Detection Of Light Stimulus Axonogenesis Vasculature Development Heparan Sulfate Proteoglycan Catabolic Process Macrophage Apoptotic Process Axon Development Isoprenoid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Proteoglycan Catabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation	Organ Morphogenesis Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Superoxide Anion Generation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cell Fate Specification Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Chondroblast Differentiation Riboflavin Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Inositol Phosphate Biosynthetic Process Regulation Of Satellite Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Sprouting Angiogenesis Anatomical Structure Morphogenesis Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process Blood Vessel Development Regulation Of Superoxide Anion Generation Vasculature Development Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Fibroblast Migration Endothelial Cell Morphogenesis Skeletal System Development Negative Regulation Of Nitric Oxide Biosynthetic Process Hyaluronan Catabolic Process Regulation Of Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Cell Fate Commitment Organ Development Regulation Of Cell Motility Regulation Of Sprouting Angiogenesis Negative Regulation Of Interleukin-12 Production Regulation Of Cell Fate Specification Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Migration Involved In Sprouting Angiogenesis Response To Stress Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Chemotaxis Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation
Tagcloud ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf	ablating accepted amniotes chicken crest deliver distance dorsal gradient heparan hitch loaded migrating migratory myotome neural onto patterning player profound proteoglycan ride secreted somite somites tube whereby wnt wnts
Tagcloud (Difference) ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf	ablating accepted amniotes chicken crest deliver distance dorsal gradient heparan hitch loaded migrating migratory myotome neural onto patterning player profound proteoglycan ride secreted somite somites tube whereby wnt wnts
Tagcloud (Intersection) ?