COL18A1

Gene Name		collagen, type XVIII, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Collagen formation Laminin interactions Collagen degradation Activation of Matrix Metalloproteinases Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009)
Protein-protein Interactions		8 interactors: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2
Entrez ID		80781
HPRD ID		00382
Ensembl ID		ENSG00000182871
Uniprot IDs		D3DSM4 D3DSM5 P39060
PDB IDs		1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Catabolic Process Angiogenesis Endoderm Formation Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Positive Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Axon Guidance Phototransduction, Visible Light Collagen Metabolic Process Blood Vessel Morphogenesis Retinoid Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Diterpenoid Metabolic Process Multicellular Organismal Metabolic Process Detection Of Visible Light Phototransduction Extracellular Matrix Disassembly Locomotion Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Blood Vessel Development Proteoglycan Metabolic Process Detection Of Light Stimulus Axonogenesis Vasculature Development Heparan Sulfate Proteoglycan Catabolic Process Macrophage Apoptotic Process Axon Development Isoprenoid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Proteoglycan Catabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation
Tagcloud ?		936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf