KISS1 and MMP16

Number of citations of the paper that reports this interaction (PMID 12879005)
19

Data Source:
HPRD (in vitro, in vivo)

		KISS1	MMP16
Gene Name		KiSS-1 metastasis-suppressor	matrix metallopeptidase 16 (membrane-inserted)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Proteinaceous Extracellular Matrix Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	Cytoskeleton Organization	Endochondral Ossification Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Craniofacial Suture Morphogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs			Marimastat Batimastat
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Schizophrenia ( 21926974 22688191)
Protein-Protein Interactions		7 interactors: APP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9	2 interactors: KISS1 LRP1
Entrez ID		3814	4325
HPRD ID		04475	03776
Ensembl ID		ENSG00000170498
Uniprot IDs		Q15726	P51512
PDB IDs			1RM8
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Ossification Endoderm Development Chondrocyte Proliferation Formation Of Primary Germ Layer Craniofacial Suture Morphogenesis Skeletal System Development Gastrulation Embryonic Morphogenesis Proteolysis Positive Regulation Of Catalytic Activity Neurogenesis Response To External Stimulus Skeletal System Morphogenesis Endochondral Ossification Response To Abiotic Stimulus Axon Guidance Nervous System Development Embryonic Cranial Skeleton Morphogenesis Embryo Development System Development Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Embryo Implantation Locomotion Endochondral Bone Morphogenesis Reproductive Process Ephrin Receptor Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Organ Development Bone Morphogenesis Synaptic Growth At Neuromuscular Junction Embryonic Skeletal System Morphogenesis Neuron Projection Morphogenesis Regulation Of Protein Binding Positive Regulation Of Peptidase Activity	Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Lipoprotein Transport Regulation Of Cholesterol Efflux Aorta Morphogenesis Aorta Development Apoptotic Cell Clearance Regulation Of Cholesterol Transport Regulation Of Smooth Muscle Cell Migration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Artery Morphogenesis Positive Regulation Of Lipid Transport Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Phospholipase Activity Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration
Tagcloud ?		ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous	ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10
Tagcloud (Difference) ?		ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous	ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10
Tagcloud (Intersection) ?