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KISS1 and MMP2
Number of citations of the paper that reports this interaction (PubMedID
12879005
)
0
Data Source:
HPRD
(in vitro, in vivo)
KISS1
MMP2
Description
KiSS-1 metastasis suppressor
matrix metallopeptidase 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Plasma Membrane
Membrane
Sarcomere
Extracellular Matrix
Molecular Function
Protein Binding
Kisspeptin Receptor Binding
Fibronectin Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Cytoskeleton Organization
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Angiogenesis
Ovarian Follicle Development
Ovulation From Ovarian Follicle
Luteinization
Response To Hypoxia
Blood Vessel Maturation
Intramembranous Ossification
Proteolysis
Response To Oxidative Stress
Negative Regulation Of Cell Adhesion
Heart Development
Female Pregnancy
Embryo Implantation
Parturition
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Peripheral Nervous System Axon Regeneration
Response To Activity
Cell Migration
Extracellular Matrix Disassembly
Protein Catabolic Process
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Response To Retinoic Acid
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Response To Nicotine
Endodermal Cell Differentiation
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Response To Estrogen
Negative Regulation Of Vasoconstriction
Ephrin Receptor Signaling Pathway
Macrophage Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Skeletal System Morphogenesis
Tissue Remodeling
Response To Electrical Stimulus
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Prostate Gland Epithelium Morphogenesis
Trophoblast Cell Migration
Cellular Response To Amino Acid Stimulus
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-1
Cellular Response To Estradiol Stimulus
Cellular Response To UV-A
Cellular Response To Fluid Shear Stress
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells
Interleukin-4 and Interleukin-13 signaling
Extra-nuclear estrogen signaling
Drugs
Marimastat
Captopril
SC-74020
Halofuginone
AE-941
Endostatin
Oleandrin
Diseases
Choriocarcinoma
Penile cancer
Torg-Winchester syndrome
GWAS
Psychosis proneness (hypomanic personality scale and perceptual aberration scale) (
28525603
)
Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) (
28525603
)
Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) (
28525603
)
Psychosis proneness (hypomanic personality scale) (
28525603
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Heel bone mineral density (
30598549
)
Lack of premeditation (
30718321
)
Refractive error (
32231278
)
Interacting Genes
9 interacting genes:
APP
CREBBP
KISS1R
MMP14
MMP16
MMP2
MMP24
MMP9
UBQLN2
40 interacting genes:
A2M
ACAN
BACE1
BCAN
CAPN3
CCL7
CCN5
CLDN1
COL18A1
COL1A1
COL6A3
COL7A1
CXCL12
DCN
EPHB2
FGFR1
HAPLN1
HSP90AA1
IGFBP3
IL1B
ITGAV
KISS1
LCN2
LGALS3
MMP14
MMP17
MMP25
MTDH
MTNR1A
MTNR1B
PZP
REL
SPOCK1
TGFB1
THBS1
THBS2
TIMP1
TIMP2
TIMP3
TIMP4
Entrez ID
3814
4313
HPRD ID
04475
00386
Ensembl ID
ENSG00000170498
ENSG00000087245
Uniprot IDs
Q15726
P08253
PDB IDs
8XGS
8ZJD
1CK7
1CXW
1EAK
1GEN
1GXD
1HOV
1J7M
1KS0
1QIB
1RTG
3AYU
7XGJ
7XJO
8H78
Enriched GO Terms of Interacting Partners
?
Collagen Catabolic Process
Collagen Metabolic Process
Extracellular Matrix Organization
Extracellular Structure Organization
Metalloendopeptidase Activity
Metallopeptidase Activity
Endodermal Cell Differentiation
Extracellular Matrix
Peptidase Activity
Extracellular Matrix Disassembly
Response To Amyloid-beta
Protein Metabolic Process
Proteolysis
Cellular Response To UV-A
Cellular Response To UV
Endopeptidase Activity
Response To Light Stimulus
Golgi Lumen
Response To UV-A
Cellular Response To Light Stimulus
Chondrocyte Proliferation
Skeletal System Morphogenesis
Extracellular Space
Craniofacial Suture Morphogenesis
Ossification
Response To Radiation
Serine-type Endopeptidase Activity
Response To UV
Metalloaminopeptidase Activity
Cellular Response To Radiation
Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Response To Stress
Skeletal System Development
Embryonic Cranial Skeleton Morphogenesis
Endochondral Ossification
Positive Regulation Of Cell Migration
Response To Mechanical Stimulus
Zinc Ion Binding
Catabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Embryo Implantation
Macromolecule Metabolic Process
Ovarian Follicle Development
Ephrin Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Extracellular Matrix
Extracellular Space
Extracellular Region
Peptidase Inhibitor Activity
Protease Binding
Metalloendopeptidase Inhibitor Activity
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Locomotion
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Membrane Protein Ectodomain Proteolysis
Cell Adhesion
Positive Regulation Of Developmental Process
Response To Cytokine
Response To Peptide
Positive Regulation Of Mononuclear Cell Migration
Response To Hormone
Skeletal System Development
Regulation Of Apoptotic Process
Endoplasmic Reticulum Lumen
Response To Mechanical Stimulus
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Cell Migration
Extracellular Matrix Binding
Regulation Of Mononuclear Cell Migration
Integrin Binding
Positive Regulation Of Leukocyte Migration
Perineuronal Net
Negative Regulation Of Multicellular Organismal Process
Serine-type Endopeptidase Inhibitor Activity
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Response To Carbohydrate
Regulation Of Proteolysis
Regulation Of Developmental Process
Basement Membrane
Regulation Of Cell Junction Assembly
Regulation Of Anatomical Structure Morphogenesis
Cell Motility
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Developmental Process
Golgi Lumen
Response To Xenobiotic Stimulus
Negative Regulation Of Metallopeptidase Activity
Angiogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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