KISS1 and MMP24

Number of citations of the paper that reports this interaction (PubMedID 12879005)
0

Data Source:
HPRD (in vitro, in vivo)

		KISS1	MMP24
Description		KiSS-1 metastasis suppressor	matrix metallopeptidase 24
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Membrane Extracellular Matrix Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Protein Binding Kisspeptin Receptor Binding	Metalloendopeptidase Activity Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Cadherin Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion	Proteolysis Cell Adhesion Glial Cell Differentiation Extracellular Matrix Organization Collagen Catabolic Process Cell-cell Adhesion Mediated By Cadherin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Activation of Matrix Metalloproteinases
Drugs			Marimastat
Diseases
GWAS		Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 18839057) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 33020668) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9 UBQLN2	2 interacting genes: BUD31 KISS1
Entrez ID		3814	10893
HPRD ID		04475	05338
Ensembl ID		ENSG00000170498	ENSG00000125966
Uniprot IDs		Q15726	Q86VV6 Q9Y5R2
PDB IDs		8XGS 8ZJD
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Metalloendopeptidase Activity Metallopeptidase Activity Endodermal Cell Differentiation Extracellular Matrix Peptidase Activity Extracellular Matrix Disassembly Response To Amyloid-beta Protein Metabolic Process Proteolysis Cellular Response To UV-A Cellular Response To UV Endopeptidase Activity Response To Light Stimulus Golgi Lumen Response To UV-A Cellular Response To Light Stimulus Chondrocyte Proliferation Skeletal System Morphogenesis Extracellular Space Craniofacial Suture Morphogenesis Ossification Response To Radiation Serine-type Endopeptidase Activity Response To UV Metalloaminopeptidase Activity Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Skeletal System Development Embryonic Cranial Skeleton Morphogenesis Endochondral Ossification Positive Regulation Of Cell Migration Response To Mechanical Stimulus Zinc Ion Binding Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Macromolecule Metabolic Process Ovarian Follicle Development Ephrin Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling	Kisspeptin Receptor Binding Positive Regulation Of Luteinizing Hormone Secretion U2-type Catalytic Step 2 Spliceosome
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