KISS1 and KISS1R

Number of citations of the paper that reports this interaction (PubMedID 11457843)
0

Data Source:
HPRD (in vitro, in vivo)

		KISS1	KISS1R
Description		KiSS-1 metastasis suppressor	KISS1 receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Cilium Cell Surface Membrane
	Molecular Function	Protein Binding Kisspeptin Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Hormone Secretion
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			ANZ-100
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP)
GWAS		Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Menopause (age at onset) ( 26414677) Sweet taste preference ( 32572145)
Interacting Genes		9 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9 UBQLN2	3 interacting genes: KISS1 PPP2CA PTPA
Entrez ID		3814	84634
HPRD ID		04475	09167
Ensembl ID		ENSG00000170498	ENSG00000116014
Uniprot IDs		Q15726	Q969F8
PDB IDs		8XGS 8ZJD	7YQE 8XGO 8XGS 8XGU 8ZJD 8ZJE
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Metalloendopeptidase Activity Metallopeptidase Activity Endodermal Cell Differentiation Extracellular Matrix Peptidase Activity Extracellular Matrix Disassembly Response To Amyloid-beta Protein Metabolic Process Proteolysis Cellular Response To UV-A Cellular Response To UV Endopeptidase Activity Response To Light Stimulus Golgi Lumen Response To UV-A Cellular Response To Light Stimulus Chondrocyte Proliferation Skeletal System Morphogenesis Extracellular Space Craniofacial Suture Morphogenesis Ossification Response To Radiation Serine-type Endopeptidase Activity Response To UV Metalloaminopeptidase Activity Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Skeletal System Development Embryonic Cranial Skeleton Morphogenesis Endochondral Ossification Positive Regulation Of Cell Migration Response To Mechanical Stimulus Zinc Ion Binding Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Macromolecule Metabolic Process Ovarian Follicle Development Ephrin Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling	Protein Phosphatase Type 2A Complex Kisspeptin Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Phosphoprotein Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Protein Tyrosine Phosphatase Activator Activity Phosphatase Activator Activity Protein Serine/threonine Phosphatase Complex Peptidyl-threonine Dephosphorylation ATPase Complex INTAC Complex Vascular Endothelial Cell Response To Fluid Shear Stress GABA Receptor Binding FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Response To Lead Ion RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Negative Regulation Of ATP Metabolic Process Calcium Channel Complex Protein Phosphatase 2A Binding Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Fluid Shear Stress T Cell Homeostasis Peptidyl-prolyl Cis-trans Isomerase Activity Nuclear RNA Surveillance RNA Surveillance Protein Phosphatase Regulator Activity Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Response To Fluid Shear Stress Negative Regulation Of Epithelial To Mesenchymal Transition Tau Protein Binding Regulation Of NLRP3 Inflammasome Complex Assembly Cytoskeleton Organization Regulation Of Glycolytic Process DNA-templated Transcription Elongation Phosphatase Binding Mesoderm Development Lymphocyte Homeostasis Regulation Of Microtubule Polymerization Regulation Of Carbohydrate Catabolic Process
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