AFF1 and SASH1

Number of citations: 53 (PubMedID 30480076)
Data Source: BioGRID (two hybrid)

		AFF1	SASH1
Name		ALF transcription elongation factor 1	SAM and SH3 domain containing 1
Structure
GO Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex Super Elongation Complex	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Gene Expression	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	None
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Apolipoprotein A1 levels ( 32203549 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Bulimia nervosa ( 23568457 ) Diastolic blood pressure ( 28234671 ) Eyebrow thickness ( 26926045 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heel bone mineral density ( 28869591 30598549 ) Hematocrit ( 27863252 32888494 29403010 ) Hematological and biochemical traits ( 31902109 ) Hemoglobin ( 32888494 29403010 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Lipoprotein (a) levels ( 33730874 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 32888494 27863252 29403010 ) Mean platelet volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Metabolic syndrome ( 31589552 ) Multiple sclerosis ( 31604244 ) PR interval ( 32439900 ) Red blood cell count ( 32888494 27863252 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 22291604 ) Total bilirubin levels ( 29403010 ) Triglyceride levels ( 32154731 30698716 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 30275531 20686565 20864672 25961943 ) White blood cell count (basophil) ( 27863252 29403010 )	Alzheimer's disease ( 20061627 ) Chronotype ( 30696823 ) Gait speed in old age ( 28077804 ) Hypothyroidism ( 27182965 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817 ) Protein quantitative trait loci ( 18464913 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rotator cuff tears ( 26350878 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Type 2 diabetes nephropathy ( 21150874 )
Novel Interactors		1 novel interactors: TBCA	None recorded
Interacting Genes		9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		4299	23328
HPRD ID		08871	06408
Ensembl ID		ENSG00000172493	ENSG00000111961
Uniprot IDs		B4DJU9 P51825 Q14C88	O94885
PDB IDs		2LM0	2DL0 2EBP
GO Terms Enriched among Interactors		Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding	Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway