SASH1 and JADE3

Number of citations: 53 (PubMedID 30480076)
Data Source: BioGRID (two hybrid)

		SASH1	JADE3
Name		SAM and SH3 domain containing 1	jade family PHD finger 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Histone Acetyltransferase Complex Nucleoplasm
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination	Regulation Of Cell Growth Regulation Of DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process
Pathways		None	HATs acetylate histones
GWAS		Alzheimer's disease ( 20061627 ) Chronotype ( 30696823 ) Gait speed in old age ( 28077804 ) Hypothyroidism ( 27182965 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817 ) Protein quantitative trait loci ( 18464913 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rotator cuff tears ( 26350878 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Type 2 diabetes nephropathy ( 21150874 )	No GWAS studies recorded
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	6 interacting genes: H3-4 MAGEA11 MTDH SASH1 TRIM55 TRIM63
Entrez ID		23328	9767
HPRD ID		06408	06675
Ensembl ID		ENSG00000111961	ENSG00000102221
Uniprot IDs		O94885	Q92613
PDB IDs		2DL0 2EBP	Not available
GO Terms Enriched among Interactors		Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway	DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Positive Regulation Of Vasculature Development Post-translational Protein Modification Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Protein Autoubiquitination Diapedesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Intercellular Canaliculus