SASH1 and EPS8L2

Number of citations of the paper that reports this interaction (PubMedID 30480076)
53

Data Source:
BioGRID (two hybrid)

		SASH1	EPS8L2
Description		SAM and SH3 domain containing 1	EPS8 signaling adaptor L2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Protein-containing Complex Cell Projection Organelle Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination	Rho Protein Signal Transduction Sensory Perception Of Sound Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly
Pathways			Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)	Keratoconus ( 33649486)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	9 interacting genes: APP PTK2 RIN3 RPL23 SASH1 SOS1 TNS2 TRIM55 TRIM63
Entrez ID		23328	64787
HPRD ID		06408	10940
Ensembl ID		ENSG00000111961	ENSG00000177106
Uniprot IDs		O94885	Q9H6S3
PDB IDs		2DL0 2EBP	1WWU 1WXB
Enriched GO Terms of Interacting Partners?		Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway	Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Molecular Function Activator Activity Regulation Of Phosphorus Metabolic Process Protein Metabolic Process Regulation Of Chemotaxis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Leukocyte Migration Amyloid-beta Complex Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Communication Cytoplasm Glial Cell Development Regulation Of Signaling Fc Receptor Signaling Pathway Heart Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mast Cell Chemotaxis Regulation Of Epithelial Cell Migration Regulation Of ATP Metabolic Process Regulation Of Receptor Internalization Protein Modification Process ERBB Signaling Pathway Developmental Growth Response To Interleukin-1 Regulation Of Cell Population Proliferation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Protein Tyrosine Phosphatase Activity GTPase Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Focal Adhesion PTB Domain Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?