AFF1 and TBCA

Data Source: HiPPIP (Novel)

		AFF1	TBCA
Name		ALF transcription elongation factor 1	tubulin folding cofactor A
Structure
GO Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex Super Elongation Complex	Nucleolus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Protein Binding	RNA Binding Protein Binding Tubulin Binding Beta-tubulin Binding Protein-folding Chaperone Binding
	Biological Process	Regulation Of Gene Expression	Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway
Pathways		None	Post-chaperonin tubulin folding pathway
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	None
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Apolipoprotein A1 levels ( 32203549 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Bulimia nervosa ( 23568457 ) Diastolic blood pressure ( 28234671 ) Eyebrow thickness ( 26926045 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heel bone mineral density ( 28869591 30598549 ) Hematocrit ( 27863252 32888494 29403010 ) Hematological and biochemical traits ( 31902109 ) Hemoglobin ( 32888494 29403010 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Lipoprotein (a) levels ( 33730874 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 32888494 27863252 29403010 ) Mean platelet volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Metabolic syndrome ( 31589552 ) Multiple sclerosis ( 31604244 ) PR interval ( 32439900 ) Red blood cell count ( 32888494 27863252 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 22291604 ) Total bilirubin levels ( 29403010 ) Triglyceride levels ( 32154731 30698716 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 30275531 20686565 20864672 25961943 ) White blood cell count (basophil) ( 27863252 29403010 )	Appendicular lean mass ( 33097823 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 )
Novel Interactors		1 novel interactors: TBCA	7 novel interactors: AFF1 CNTN4 EDIL3 LHFPL2 PAM PHAX RAG1
Interacting Genes		9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9	5 interacting genes: CDC42 CEBPA ERBB3 TAF9 TERF2IP
Entrez ID		4299	6902
HPRD ID		08871	18166
Ensembl ID		ENSG00000172493	ENSG00000171530
Uniprot IDs		B4DJU9 P51825 Q14C88	E5RIX8 O75347 Q6FGD7
PDB IDs		2LM0	1H7C
GO Terms Enriched among Interactors		Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding	None