AFF1 and NT5E

Number of citations of the paper that reports this interaction (PMID 19956800)
53

Data Source:
BioGRID (two hybrid)

		AFF1	NT5E
Gene Name		AF4/FMR2 family, member 1	5-nucleotidase, ecto (CD73)
Image
Gene Ontology Annotations	Cellular Component	Transcription Elongation Factor Complex	Cytoplasm Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Transcription, DNA-templated	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process AMP Catabolic Process Pyrimidine Nucleobase Metabolic Process DNA Metabolic Process Dephosphorylation Small Molecule Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response Nucleobase-containing Small Molecule Metabolic Process
Pathways			Purine catabolism Pyrimidine catabolism Purine metabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs			Pentoxifylline
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 22291604) Triglycerides ( 20864672 20686565)	Metabolic traits ( 21886157)
Protein-Protein Interactions		7 interactors: HIST3H3 MLLT1 MLLT3 NT5E SIAH1 SIAH2 SMAD9	4 interactors: ACTB AFF1 FN1 LAMA1
Entrez ID		4299	4907
HPRD ID		08871	00552
Ensembl ID		ENSG00000172493	ENSG00000135318
Uniprot IDs		P51825 Q14C88	P21589 Q6NZX3
PDB IDs		2LM0	4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I
Enriched GO Terms of Interacting Partners?		Adenosine Biosynthetic Process AMP Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Purine Nucleoside Monophosphate Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mullerian Duct Regression Cellular Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Purine Ribonucleoside Catabolic Process Nucleobase-containing Compound Metabolic Process AMP Metabolic Process Adenosine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Segment Specification Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axon Guidance Anatomical Structure Regression Pyrimidine Nucleoside Catabolic Process Cellular Nitrogen Compound Metabolic Process Protein Destabilization Purine Ribonucleotide Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nitrogen Compound Metabolic Process	Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Platelet Activation Cell Junction Assembly Cell Adhesion Locomotion Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Movement Of Cell Or Subcellular Component Generation Of Neurons Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Neurogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Establishment Of Monopolar Cell Polarity Cell Development Blood Coagulation Blood Vessel Morphogenesis Hemostasis Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Blood Vessel Development Axonogenesis Establishment Of Epithelial Cell Polarity Vasculature Development Axon Development Nervous System Development Regulation Of Body Fluid Levels Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Retina Vasculature Development In Camera-type Eye Anatomical Structure Morphogenesis Morphogenesis Of A Polarized Epithelium Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Activation Response To Wounding Branching Involved In Salivary Gland Morphogenesis Substantia Nigra Development Endodermal Cell Differentiation Platelet Aggregation Acute-phase Response Neuron Projection Development Positive Regulation Of Axon Extension Cell Projection Morphogenesis
Tagcloud ?		abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa
Tagcloud (Difference) ?		abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa
Tagcloud (Intersection) ?