AFF1 and MLLT3

Number of citations of the paper that reports this interaction (PMID 21729782)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		AFF1	MLLT3
Gene Name		AF4/FMR2 family, member 1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Image
Gene Ontology Annotations	Cellular Component	Transcription Elongation Factor Complex	Nucleus Transcription Elongation Factor Complex Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Segment Specification Anterior/posterior Pattern Specification Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 22291604) Triglycerides ( 20864672 20686565)
Protein-Protein Interactions		7 interactors: HIST3H3 MLLT1 MLLT3 NT5E SIAH1 SIAH2 SMAD9	12 interactors: AFF1 APP APPBP2 BCOR CBX8 CDK6 EEF1A1 LRIF1 MCM6 PTN RBM48 SGK1
Entrez ID		4299	4300
HPRD ID		08871	01163
Ensembl ID		ENSG00000172493	ENSG00000171843
Uniprot IDs		P51825 Q14C88	B7Z755 P42568 Q6MZE2 Q8IVB0
PDB IDs		2LM0	2LM0
Enriched GO Terms of Interacting Partners?		Adenosine Biosynthetic Process AMP Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Purine Nucleoside Monophosphate Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mullerian Duct Regression Cellular Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Purine Ribonucleoside Catabolic Process Nucleobase-containing Compound Metabolic Process AMP Metabolic Process Adenosine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Segment Specification Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axon Guidance Anatomical Structure Regression Pyrimidine Nucleoside Catabolic Process Cellular Nitrogen Compound Metabolic Process Protein Destabilization Purine Ribonucleotide Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nitrogen Compound Metabolic Process	Histone Ubiquitination Learning Or Memory Cognition Regulation Of Gene Expression Cell Dedifferentiation Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Ossification Regulation Of Metabolic Process Negative Regulation Of Tooth Mineralization Synaptic Growth At Neuromuscular Junction Regulation Of Transcription, DNA-templated Single-organism Behavior Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Renal Sodium Ion Absorption Learning Notch Signaling Pathway Behavior Collateral Sprouting Renal Sodium Ion Transport Axon Midline Choice Point Recognition Specification Of Axis Polarity G1/S Transition Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Odontogenesis Axon Choice Point Recognition Regulation Of Gastric Acid Secretion Negative Regulation Of Histone H3-K4 Methylation Regulation Of Ossification Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Remodeling Negative Regulation Of Cellular Senescence Histone H2A Monoubiquitination Renal Absorption Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Hematopoietic Stem Cell Differentiation DNA Unwinding Involved In DNA Replication
Tagcloud ?		abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	af af9 all1 associate brd4 bridging bromodomain coactivators corepressors elongation enabling engage establishes extends fingerprinting initiate interactome links modulators p19 pluripotent preinitiation rar retinoid tefb transcribed transitions unravel unsuspected
Tagcloud (Difference) ?		abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	af af9 all1 associate brd4 bridging bromodomain coactivators corepressors elongation enabling engage establishes extends fingerprinting initiate interactome links modulators p19 pluripotent preinitiation rar retinoid tefb transcribed transitions unravel unsuspected
Tagcloud (Intersection) ?		mllt3