SASH1 and SECISBP2L

Number of citations: 53 (PubMedID 30480076)
Data Source: BioGRID (two hybrid)

		SASH1	SECISBP2L
Name		SAM and SH3 domain containing 1	SECIS binding protein 2 like
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Mitochondrion Ribonucleoprotein Complex
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding Selenocysteine Insertion Sequence Binding Ribonucleoprotein Complex Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination	Selenocysteine Incorporation
GWAS		Alzheimer's disease ( 20061627 ) Chronotype ( 30696823 ) Gait speed in old age ( 28077804 ) Hypothyroidism ( 27182965 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817 ) Protein quantitative trait loci ( 18464913 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rotator cuff tears ( 26350878 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Type 2 diabetes nephropathy ( 21150874 )	Alcohol consumption (drinks per week) ( 30643258 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung adenocarcinoma ( 28604730 31326317 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Weight ( 28552196 )
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	2 interacting genes: RNF10 SASH1
Entrez ID		23328	9728
HPRD ID		06408	17181
Ensembl ID		ENSG00000111961	ENSG00000138593
Uniprot IDs		O94885	Q93073
PDB IDs		2DL0 2EBP	Not available
GO Terms Enriched among Interactors		Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway	Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Positive Regulation Of Response To Food Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Kinase Activity Regulation Of Multicellular Organismal Development Positive Regulation Of Appetite Negative Regulation Of Osteoclast Development Negative Regulation Of Cell Development Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase A Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Protein Autoubiquitination Post-embryonic Eye Morphogenesis Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Extracellular Negative Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Osteoclast Development Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Protein Kinase A Signaling Positive Regulation Of JUN Kinase Activity Microfibril Regulation Of Protein K63-linked Ubiquitination Regulation Of Developmental Process Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Response To Food Negative Regulation Of Glial Cell Proliferation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Myelination Protein Ubiquitination Regulation Of Protein Modification Process Regulation Of Appetite Negative Regulation Of Cell Differentiation Embryonic Eye Morphogenesis Positive Regulation Of P38MAPK Cascade Regulation Of Multicellular Organismal Process Cell Adhesion Mediated By Integrin