SASH1 and C1D

Number of citations of the paper that reports this interaction (PubMedID 30480076)
53

Data Source:
BioGRID (two hybrid)

		SASH1	C1D
Description		SAM and SH3 domain containing 1	C1D nuclear receptor corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Repressor Complex
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination	Maturation Of 5.8S RRNA RRNA Processing Apoptotic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)	Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) PR interval ( 32439900) Restless legs syndrome ( 29029846) Schizophrenia x sex interaction ( 34099189) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	15 interacting genes: APP GSC2 IL23R NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 SH3GLB1 SUOX THRA THRB TSNAX ZGPAT
Entrez ID		23328	10438
HPRD ID		06408	07382
Ensembl ID		ENSG00000111961	ENSG00000197223
Uniprot IDs		O94885	Q13901
PDB IDs		2DL0 2EBP
Enriched GO Terms of Interacting Partners?		Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway	Negative Regulation Of MiRNA Transcription Mating Behavior Sequence-specific DNA Binding Chromatin Thyroid Hormone Receptor Signaling Pathway Female Courtship Behavior Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway DNA Binding Reproductive Behavior Thyroid Hormone Binding Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Female Receptivity Female Mating Behavior Type I Pneumocyte Differentiation Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Rhythmic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Regulation Of Ketone Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Lung Epithelial Cell Differentiation Lung Cell Differentiation Nuclear Body Negative Regulation Of Phosphate Metabolic Process Regulation Of Androgen Receptor Signaling Pathway
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