SASH1 and EXOC8

Number of citations of the paper that reports this interaction (PubMedID 30480076)
53

Data Source:
BioGRID (two hybrid)

		SASH1	EXOC8
Description		SAM and SH3 domain containing 1	exocyst complex component 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Exocyst Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Protein Binding Small GTPase Binding Phosphatidylinositol Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Endosome Organization Intracellular Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)	Hemoglobin concentration ( 27863252)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4
Entrez ID		23328	149371
HPRD ID		06408	09943
Ensembl ID		ENSG00000111961	ENSG00000116903
Uniprot IDs		O94885	Q8IYI6
PDB IDs		2DL0 2EBP
Enriched GO Terms of Interacting Partners?		Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Binding Supramolecular Fiber Organization Intermediate Filament Organelle Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Cytoskeleton Regulation Of Viral Transcription Regulation Of Post-translational Protein Modification Regulation Of Protein Autoubiquitination Molecular Adaptor Activity Cytoskeleton Organization Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Cellular Localization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Lysosome Size BORC Complex Post-mRNA Release Spliceosomal Complex Gamma-tubulin Binding Autophagosome Epidermis Development
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