AFF1 and ARFIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AFF1	ARFIP1
Description		ALF transcription elongation factor 1	ARF interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex Super Elongation Complex	Golgi Membrane Golgi Apparatus Cytosol Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Protein Domain Specific Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Regulation Of Gene Expression	Intracellular Protein Transport Intracellular Protein Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Protein Secretion Negative Regulation Of Retrograde Transport, Endosome To Golgi
Pathways
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 27863252 32888494 29403010) Hematological and biochemical traits ( 31902109) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252 29403010) Mean corpuscular volume ( 32888494 27863252 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 32154731 30698716 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531 20686565 20864672 25961943) White blood cell count (basophil) ( 27863252 29403010)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9	18 interacting genes: AFF1 ARF1 ARF3 ARF5 BSND CMTM5 DESI2 KRT27 KRT33B MAGEA6 RPRM SCAMP1 SFT2D1 SLC2A4 SMIM5 SMPD2 SYNGR3 TNFRSF10D
Entrez ID		4299	27236
HPRD ID		08871	09331
Ensembl ID		ENSG00000172493	ENSG00000164144
Uniprot IDs		B4DJU9 P51825 Q14C88	B4E273 P53367 Q8N8M9
PDB IDs		2LM0
Enriched GO Terms of Interacting Partners?		Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding
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