SASH1 and PPP4R1

Number of citations of the paper that reports this interaction (PubMedID 30480076)
53

Data Source:
BioGRID (two hybrid)

		SASH1	PPP4R1
Description		SAM and SH3 domain containing 1	protein phosphatase 4 regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Protein Phosphatase 4 Complex
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination	Protein Phosphorylation Signal Transduction
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)	Lean body mass ( 28552196) Metabolite levels ( 23823483) Platelet distribution width ( 27863252)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	6 interacting genes: CEP63 DISC1 DSCR9 HDAC3 PPP4C SASH1
Entrez ID		23328	9989
HPRD ID		06408	05366
Ensembl ID		ENSG00000111961	ENSG00000154845
Uniprot IDs		O94885	Q8TF05
PDB IDs		2DL0 2EBP
Enriched GO Terms of Interacting Partners?		Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway	Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Polyubiquitination Molecular Adaptor Activity Regulation Of Protein K63-linked Ubiquitination Microtubule Cytoskeleton Organization Positive Regulation Of Ferroptosis Spindle Assembly Neural Precursor Cell Proliferation Centrosome Regulation Of Protein Modification Process Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Regulation Of Protein Metabolic Process Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Spindle Organization Protein Decrotonylase Activity Histone Decrotonylase Activity Organelle Assembly Protein Phosphatase 4 Complex Positive Regulation Of Protein Metabolic Process Cornified Envelope Assembly Microtubule-based Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Protein Autoubiquitination Radial Glia-guided Pyramidal Neuron Migration Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Phosphorylation Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Protein Polyubiquitination Positive Regulation Of Phosphorylation Cytoskeleton Organization Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Cardiac Muscle Cell Differentiation Cellular Response To Parathyroid Hormone Stimulus Membraneless Organelle Assembly Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
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