SASH1

Name	SAM and SH3 domain containing 1
Structure
Interactors	26 interactors: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination
GWAS	Alzheimer's disease ( 20061627 ) Chronotype ( 30696823 ) Gait speed in old age ( 28077804 ) Hypothyroidism ( 27182965 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817 ) Protein quantitative trait loci ( 18464913 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rotator cuff tears ( 26350878 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Type 2 diabetes nephropathy ( 21150874 )
Entrez ID	23328
HPRD ID	06408
Ensembl ID	ENSG00000111961
Uniprot IDs	O94885
PDB IDs	2DL0 2EBP
GO Terms Enriched among Interactors ?	Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway