MEP1A and TAC1

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1A	TAC1
Description		meprin A subunit alpha	tachykinin precursor 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space Axon Neuronal Cell Body Synapse Neuronal Dense Core Vesicle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity	Protein Binding Substance P Receptor Binding Neuromedin K Receptor Binding Substance K Receptor Binding Receptor Ligand Activity
	Biological Process	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing	Response To Yeast Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Innate Immune Response Positive Regulation Of Action Potential Positive Regulation Of Ossification Response To Pain Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Stress Fiber Assembly Regulation Of Sensory Perception Of Pain Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Sensory Perception Of Pain Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion
Pathways			Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6
Entrez ID		4224	6863
HPRD ID		02666	08876
Ensembl ID		ENSG00000112818	ENSG00000006128
Uniprot IDs		B7ZL91 Q16819	P20366 Q9Y494
PDB IDs		7UAB 7UAC 7UAE 7UAF 7UAI	2B19 2KS9 2KSA 2KSB 4HOM 7P00 7P02 7RMG 7RMH 7VDM 7XWO 8JBH 8U26
Enriched GO Terms of Interacting Partners?		Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen	Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Sperm Head Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Membrane Cyclin Binding Regulation Of Reproductive Process Response To Electrical Stimulus Peptide Hormone Processing Regulation Of Hormone Levels Signaling Receptor Ligand Precursor Processing Regulation Of Cell Motility Regulation Of Vascular Permeability Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Regulation Of Biological Quality Smooth Muscle Contraction Regulation Of Microtubule-based Process Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Maturation Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Angiotensin-mediated Drinking Behavior Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Regulation Of Multicellular Organismal Process
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