MEP1A and KNG1

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1A	KNG1
Description		meprin A subunit alpha	kininogen 1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Hormone Activity Protein Binding Heparin Binding Zinc Ion Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing	Inflammatory Response Negative Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Killing Of Cells Of Another Organism Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Multicellular Organismal Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Activated partial thromboplastin time ( 20303064 22703881 29403010) Adiponectin levels ( 20876611) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	29 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CRYAA CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		4224	3827
HPRD ID		02666	01970
Ensembl ID		ENSG00000112818	ENSG00000113889
Uniprot IDs		B7ZL91 Q16819	P01042
PDB IDs		7UAB 7UAC 7UAE 7UAF 7UAI	1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y 7EIB 7F2O 7F6H 7F6I 7QOT 7QOX 8VJX
Enriched GO Terms of Interacting Partners?		Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen	Peptidase Activity Protein Maturation Protein Processing Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Regulation Of Blood Coagulation Regulation Of Hemostasis Proteolysis Serine-type Peptidase Activity Extracellular Space Regulation Of Wound Healing Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Region Negative Regulation Of Coagulation Protein Metabolic Process Regulation Of Response To Wounding Negative Regulation Of Wound Healing Hydrolase Activity Regulation Of Biological Quality Fibrinolysis External Side Of Plasma Membrane Regulation Of Body Fluid Levels Negative Regulation Of Fibrinolysis Proteoglycan Binding Peptide Hormone Processing Heparin Binding Signaling Receptor Ligand Precursor Processing Extracellular Matrix Disassembly Positive Regulation Of Fibrinolysis Blood Coagulation Extracellular Matrix Coagulation Hemostasis Endolysosome Lumen Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Multicellular Organismal Process Fibronectin Binding Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Zymogen Activation Hormone Metabolic Process Neutrophil-mediated Killing Of Bacterium Lysosome
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