MEP1A and CCK

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1A	CCK
Description		meprin A subunit alpha	cholecystokinin
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space Axon
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Camostat
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 24348519 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
Entrez ID		4224	885
HPRD ID		02666	00321
Ensembl ID		ENSG00000112818	ENSG00000187094
Uniprot IDs		B7ZL91 Q16819	P06307 Q6FG82
PDB IDs		7UAB 7UAC 7UAE 7UAF 7UAI	7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK
Enriched GO Terms of Interacting Partners?		Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen	Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?