MEP1A and GNRH1

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		MEP1A	GNRH1
Gene Name		meprin A, alpha (PABA peptide hydrolase)	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Hormone Activity Gonadotropin Hormone-releasing Hormone Activity
	Biological Process	Proteolysis Digestion	Signal Transduction Cell-cell Signaling Multicellular Organismal Development Female Pregnancy Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Response To Corticosteroid Ovulation Cycle Negative Regulation Of Apoptotic Process Response To Ethanol Regulation Of Ovarian Follicle Development Negative Regulation Of Neuron Migration
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	2 interactors: GNRHR MEP1A
Entrez ID		4224	2796
HPRD ID		02666	08860
Ensembl ID		ENSG00000112818	ENSG00000147437
Uniprot IDs		B7ZL91 Q16819	P01148
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process	Cellular Response To Gonadotropin-releasing Hormone
Tagcloud ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	12h absolutely acting breeding counter darkness daylight exceed gradually happens latitudes naturally net photo photoperiod photoperiods photorefractory prevailing progresses proposes protocols reverses reviews seasons secretion sometimes tandem timing
Tagcloud (Difference) ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	12h absolutely acting breeding counter darkness daylight exceed gradually happens latitudes naturally net photo photoperiod photoperiods photorefractory prevailing progresses proposes protocols reverses reviews seasons secretion sometimes tandem timing
Tagcloud (Intersection) ?