MEP1A and GNRH1

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1A	GNRH1
Description		meprin A subunit alpha	gonadotropin releasing hormone 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space Golgi-associated Vesicle Dendrite Perikaryon Axon Terminus Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Neurosecretory Vesicle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity	Hormone Activity Gonadotropin Hormone-releasing Hormone Activity Gonadotropin-releasing Hormone Receptor Binding
	Biological Process	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing	Signal Transduction Cell-cell Signaling Female Pregnancy Regulation Of Gene Expression Regulation Of Signaling Male Sex Determination Response To Lipopolysaccharide Negative Regulation Of Immature T Cell Proliferation Response To Testosterone Response To Prostaglandin E Response To Potassium Ion Ovulation Cycle Negative Regulation Of Apoptotic Process Response To Peptide Hormone Estrous Cycle Response To Ethanol Response To Steroid Hormone Response To Prolactin Regulation Of Ovarian Follicle Development Negative Regulation Of Neuron Migration
Pathways			Hormone ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Length of menstrual cycle ( 30202859) Menopause (age at onset) ( 29773799) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	2 interacting genes: GNRHR MEP1A
Entrez ID		4224	2796
HPRD ID		02666	08860
Ensembl ID		ENSG00000112818	ENSG00000147437
Uniprot IDs		B7ZL91 Q16819	P01148
PDB IDs		7UAB 7UAC 7UAE 7UAF 7UAI	4D5M
Enriched GO Terms of Interacting Partners?		Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen	Gonadotropin-releasing Hormone Receptor Activity Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Response To Gonadotropin-releasing Hormone Gonadotropin Secretion Regulation Of Hormone Levels Cellular Response To Gonadotropin-releasing Hormone Metallodipeptidase Activity Protein-hormone Receptor Activity Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing
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