MEP1A and GRP

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		MEP1A	GRP
Gene Name		meprin A, alpha (PABA peptide hydrolase)	gastrin-releasing peptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Receptor Binding Neuropeptide Hormone Activity
	Biological Process	Proteolysis Digestion	Signal Transduction Neuropeptide Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	4 interactors: DPP4 GRPR MEP1A MEP1B
Entrez ID		4224	2922
HPRD ID		02666	08845
Ensembl ID		ENSG00000112818	ENSG00000134443
Uniprot IDs		B7ZL91 Q16819	P07492
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process See more	Digestion Bombesin Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Extracellular Matrix Organization Proteolysis Regulation Of Cell-cell Adhesion Mediated By Integrin
Tagcloud ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	activators arsenite cations chaperones chemicals coordinate coupling cycling describing emphasized grp78 grps homeostatic hsp hsps integrative loading misfolding mobilizing modeled oxidants pertaining processing relates relating relationships thiol translation trigger
Tagcloud (Difference) ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	activators arsenite cations chaperones chemicals coordinate coupling cycling describing emphasized grp78 grps hsp hsps integrative loading misfolding mobilizing modeled oxidants pertaining processing relates relating relationships thiol translation trigger
Tagcloud (Intersection) ?		homeostatic