MEP1A and POMC

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		MEP1A	POMC
Gene Name		meprin A, alpha (PABA peptide hydrolase)	proopiomelanocortin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Proteolysis Digestion	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Peptide Hormone Processing Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins G alpha (s) signalling events Glucocorticoid biosynthesis Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Peptide hormone metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Peptide ligand-binding receptors Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Peptide hormone biosynthesis G alpha (i) signalling events Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Opioid Signalling Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) GPCR ligand binding Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) GPCR downstream signaling Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) G-protein activation Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS			Body mass index ( 23669352 20935630) Height ( 23563607 18391951) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	12 interactors: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRD1 PAM VTN
Entrez ID		4224	5443
HPRD ID		02666	01462
Ensembl ID		ENSG00000112818	ENSG00000115138
Uniprot IDs		B7ZL91 Q16819	P01189 Q6FHC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Behavior Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Neuromuscular Junction Development Innate Immune Response Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Positive Regulation Of White Fat Cell Proliferation Semicircular Canal Fusion Bronchiole Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Lung Development Response To Stimulus Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of White Fat Cell Proliferation Synaptic Growth At Neuromuscular Junction Tear Secretion Semicircular Canal Formation Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Branch Elongation Involved In Salivary Gland Morphogenesis Peptide Amidation Homoiothermy Feeding Behavior Signal Transduction Positive Regulation Of Fat Cell Proliferation Bronchiole Development Submandibular Salivary Gland Formation Female Genitalia Morphogenesis Collateral Sprouting In Absence Of Injury
Tagcloud ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently
Tagcloud (Difference) ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently
Tagcloud (Intersection) ?