MEP1A and PTH

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MEP1A	PTH
Description		meprin A subunit alpha	parathyroid hormone
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing	Skeletal System Development Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Bone Mineralization Positive Regulation Of Bone Mineralization Response To Nutrient Levels Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of D-glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Phosphate Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Pathways			Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			D-norleucine ABX-PTH
Diseases
GWAS			Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	6 interacting genes: ASPH BAG6 FEZ1 MEP1A PTH1R PTH2R
Entrez ID		4224	5741
HPRD ID		02666	01345
Ensembl ID		ENSG00000112818	ENSG00000152266
Uniprot IDs		B7ZL91 Q16819	P01270
PDB IDs		7UAB 7UAC 7UAE 7UAF 7UAI	1BWX 1ET1 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M 7VVK 7VVL 7VVM 7VVN 7VVO 7Y36 8FLQ 8HA0 8HAO 8T5F 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen	Parathyroid Hormone Receptor Activity Regulation Of Intracellular Transport Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Glycosylation-dependent Protein Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control ERAD Pathway Regulation Of Cellular Localization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity BAT3 Complex Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Maintenance Of Unfolded Protein Positive Regulation Of Proteolysis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Sarcoplasmic Reticulum Lumen Intracellular Calcium Ion Homeostasis Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Homeostasis Cortical Endoplasmic Reticulum Metallodipeptidase Activity Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Response To Endoplasmic Reticulum Stress Protein Targeting Protein Carrier Chaperone NK T Cell Activation Regulation Of Organelle Transport Along Microtubule Protein Retention In ER Lumen Negative Regulation Of Protein Exit From Endoplasmic Reticulum Hrd1p Ubiquitin Ligase Complex Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
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