MEN1 and MYH9

Number of citations of the paper that reports this interaction (PMID 14508515)
10

Data Source:
HPRD (in vivo, in vitro)

		MEN1	MYH9
Gene Name		multiple endocrine neoplasia I	myosin, heavy chain 9, non-muscle
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Cleavage Furrow Histone Methyltransferase Complex Protein Complex	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein Binding, Bridging Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding R-SMAD Binding	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Leukocyte Homeostasis Negative Regulation Of Protein Phosphorylation Osteoblast Fate Commitment Osteoblast Development DNA Repair Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Cell Proliferation Response To UV Response To Gamma Radiation Gene Expression Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Methylation Positive Regulation Of Protein Binding Regulation Of Activin Receptor Signaling Pathway Histone Lysine Methylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Embryonic Skeletal System Morphogenesis Positive Regulation Of Cell Division Negative Regulation Of Telomerase Activity Palate Development Maternal Process Involved In Female Pregnancy	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer formation of the beta-catenin:TCF transactivating complex Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer	EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS		Urate levels ( 21768215)	End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		32 interactors: ASH2L CTNNB1 DBF4 ESR1 FANCD2 FOXN3 GFAP HDAC1 HDAC2 HIST1H3A HIST3H3 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF4 TP53 VIM	22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ
Entrez ID		4221	4627
HPRD ID		00564	01177
Ensembl ID		ENSG00000133895	ENSG00000100345
Uniprot IDs		O00255 Q9GZQ5	P35579
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80	2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Chromosome Organization RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Response To Stress Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cell Differentiation Cellular Response To Stimulus Anatomical Structure Development Response To Stimulus Chromatin Organization Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Organelle Organization Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Differentiation	Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development
Tagcloud ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Difference) ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Intersection) ?