MEN1 and TCF7L2

Number of citations of the paper that reports this interaction (PubMedID 19074834)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MEN1	TCF7L2
Description		menin 1	transcription factor 7 like 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Transcription Repressor Complex Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex	Chromatin Nucleus Nucleoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Beta-catenin-TCF Complex
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Phosphoprotein Binding R-SMAD Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Nuclear Receptor Binding Protein Kinase Binding Sequence-specific DNA Binding Gamma-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Armadillo Repeat Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity T-helper 2 Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Wnt Signaling Pathway Pancreas Development Positive Regulation Of Insulin Secretion Regulation Of Hormone Metabolic Process Glucose Homeostasis Maintenance Of DNA Repeat Elements Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Formation of definitive endoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Adrenal carcinoma Malignant islet cell carcinoma Carcinoid	Type II diabetes mellitus
GWAS		Urate levels ( 21768215)	Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder (body mass index interaction) ( 24322204) Blood glucose levels ( 29615537 31928498) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 26426971 28448500 28892062 29381148 31453325) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 27117709) Breast Cancer in BRCA1 mutation carriers ( 23544013) Childhood onset type 2 diabetes ( 33479058) Circulating leptin levels or type 2 diabetes ( 32341051) Clinical laboratory measurements ( 27897004) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 24836286 29471430 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138) Glycated hemoglobin levels ( 20849430 28898252 34059833) Glycemic traits (pleiotropy) ( 31021400) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte count ( 32888494) High myopia ( 31816047 33830181) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertrophic cardiomyopathy ( 33495597) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Ischemic stroke ( 26732560) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Mild obesity-related type 2 diabetes ( 34737425) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myopia ( 27182965) Offspring birth weight ( 31043758) Peak insulin response ( 28490609) Peripheral artery disease ( 31285632) Proinsulin levels ( 21873549) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Retinopathy x type 2 diabetes interaction ( 32541925) Schizophrenia vs type 2 diabetes ( 30470734) Severe insulin-deficient type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17293876 17460697 17463246 17463248 17463249 17554300 17668382 18372903 19056611 19401414 19734900 20581827 21347282 22101970 22693455 22885922 23209189 23300278 23945395 24390345 24509480 25102180 25483131 26818947 26961502 27189021 28254843 28869590 29358691 30054458 30297969 30470734 30718926 31049640 31118516 31324766 32499647 34737425) Urate levels ( 31578528) Waist circumference ( 25673412) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		31 interacting genes: ANXA1 ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM	46 interacting genes: ACTMAP AR BPIFA1 CCNG2 CNFN CRX CSNK2A1 CSNK2A2 CTNNB1 CTNNBIP1 CYSRT1 DAXX DAZAP2 EP300 FAM168B FBLN1 HIC1 INTS11 JUP KCNE4 KMT5A KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 MEN1 MSX2 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSMA3 RBPMS RNF138 SMUG1 TLE5 TRAF1 TSC1 UFSP1 ZNF34
Entrez ID		4221	6934
HPRD ID		00564	03751
Ensembl ID		ENSG00000133895	ENSG00000148737
Uniprot IDs		A0A5F9ZHS3 A0AA75I0P0 E7EN32 O00255 Q9GZQ5	A0A0A0MTL7 A0A994J711 B4DJZ2 C6ZRJ7 C6ZRK1 C6ZRK2 C6ZRK5 Q5JRY4 Q5VVR7 Q6FHW4 Q9NQB0
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6S2K 6WNH 7M4T 7O9T 7O9X 7O9Z 7OA9 7UJ4 8E90 8GPN 8IG0 8VA5 8VA6 9C92 9C93 9C94	1JDH 1JPW 2GL7
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Growth Factor Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process I-SMAD Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor Binding Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Enzyme Binding Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription	Intermediate Filament Wnt Signaling Pathway Nuclear Receptor Binding Beta-catenin-ICAT Complex Regulation Of Wnt Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Protein Kinase CK2 Complex Catenin-TCF7L2 Complex Keratinization Cellular Response To Indole-3-methanol Response To Indole-3-methanol Transcription Coactivator Activity Cell Surface Receptor Signaling Pathway Beta-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Canonical Wnt Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Epithelial Cell Differentiation Involved In Prostate Gland Development DNA Damage Response Protein-DNA Complex Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Signal Transduction By P53 Class Mediator Alpha-catenin Binding Transcription Coactivator Binding Cytosol Negative Regulation Of Apoptotic Signaling Pathway Genitalia Morphogenesis Beta-catenin Destruction Complex Pre-mRNA Intronic Binding Cornified Envelope Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Osteoblast Differentiation Regulation Of RNA Metabolic Process Regionalization Osteoblast Development Protein-containing Complex Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Osteoblast Differentiation P53 Binding
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