MEN1 and RBBP5

Number of citations of the paper that reports this interaction (PMID 14992727)
152

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MEN1	RBBP5
Gene Name		multiple endocrine neoplasia I	retinoblastoma binding protein 5
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Cleavage Furrow Histone Methyltransferase Complex Protein Complex	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein Binding, Bridging Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding R-SMAD Binding	Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Leukocyte Homeostasis Negative Regulation Of Protein Phosphorylation Osteoblast Fate Commitment Osteoblast Development DNA Repair Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Cell Proliferation Response To UV Response To Gamma Radiation Gene Expression Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Methylation Positive Regulation Of Protein Binding Regulation Of Activin Receptor Signaling Pathway Histone Lysine Methylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Embryonic Skeletal System Morphogenesis Positive Regulation Of Cell Division Negative Regulation Of Telomerase Activity Palate Development Maternal Process Involved In Female Pregnancy	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Response To Estrogen Histone H3-K4 Methylation
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer formation of the beta-catenin:TCF transactivating complex Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer	Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		32 interactors: ASH2L CTNNB1 DBF4 ESR1 FANCD2 FOXN3 GFAP HDAC1 HDAC2 HIST1H3A HIST3H3 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF4 TP53 VIM	10 interactors: CHD8 CTBP1 CTNNB1 HIST2H3C HIST3H3 KMT2A MEN1 RB1 TP53 UBE2I
Entrez ID		4221	5929
HPRD ID		00564	02826
Ensembl ID		ENSG00000133895	ENSG00000117222
Uniprot IDs		O00255 Q9GZQ5	B4DLF8 Q15291
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80	3P4F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Chromosome Organization RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Response To Stress Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cell Differentiation Cellular Response To Stimulus Anatomical Structure Development Response To Stimulus Chromatin Organization Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Organelle Organization Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Differentiation	Positive Regulation Of Histone Modification Regulation Of Chromosome Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Positive Regulation Of Organelle Organization Chromosome Organization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Organelle Organization Chromatin Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Histone Methylation Regulation Of Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Histone Methylation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Modification Regulation Of RNA Metabolic Process Hemopoiesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Glial Cell Apoptotic Process Heterocycle Metabolic Process Immune System Development Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Histone H3-K4 Methylation
Tagcloud ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Difference) ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Intersection) ?