MEN1 and JUND

Number of citations of the paper that reports this interaction (PubMedID 35850772)
65

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MEN1	JUND
Description		menin 1	JunD proto-oncogene, AP-1 transcription factor subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Transcription Repressor Complex Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-containing Complex Protein-DNA Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Phosphoprotein Binding R-SMAD Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity T-helper 2 Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Circadian Rhythm Response To Light Stimulus Response To Mechanical Stimulus Gene Expression Response To Lipopolysaccharide Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Cell Cycle Cellular Response To Calcium Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Forskolin
Pathways		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Adrenal carcinoma Malignant islet cell carcinoma Carcinoid
GWAS		Urate levels ( 21768215)	Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 30604766 31015462) Hand grip strength ( 29691431) Systemic lupus erythematosus ( 33536424) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)
Interacting Genes		31 interacting genes: ANXA1 ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM	30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 MIR9-2HG NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		4221	3727
HPRD ID		00564	01304
Ensembl ID		ENSG00000133895	ENSG00000130522
Uniprot IDs		A0A5F9ZHS3 A0AA75I0P0 E7EN32 O00255 Q9GZQ5	P17535
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6S2K 6WNH 7M4T 7O9T 7O9X 7O9Z 7OA9 7UJ4 8E90 8GPN 8IG0 8VA5 8VA6 9C92 9C93 9C94	3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 7UCC 7UCD
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Growth Factor Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process I-SMAD Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor Binding Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Enzyme Binding Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of Metabolic Process Intracellular Signal Transduction RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Nucleoplasm DNA Binding Cellular Response To Stress Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To Nutrient Levels Intracellular Signaling Cassette Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Negative Regulation Of Metabolic Process Response To Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Enzyme Binding R-SMAD Binding DNA-templated Transcription DNA Damage Response
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