MEN1 and DBF4

Number of citations of the paper that reports this interaction (PMID 15374998)
13

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		MEN1	DBF4
Gene Name		multiple endocrine neoplasia I	DBF4 zinc finger
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Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Cleavage Furrow Histone Methyltransferase Complex Protein Complex	Nucleoplasm
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein Binding, Bridging Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding R-SMAD Binding	Nucleic Acid Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Leukocyte Homeostasis Negative Regulation Of Protein Phosphorylation Osteoblast Fate Commitment Osteoblast Development DNA Repair Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Cell Proliferation Response To UV Response To Gamma Radiation Gene Expression Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Methylation Positive Regulation Of Protein Binding Regulation Of Activin Receptor Signaling Pathway Histone Lysine Methylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Embryonic Skeletal System Morphogenesis Positive Regulation Of Cell Division Negative Regulation Of Telomerase Activity Palate Development Maternal Process Involved In Female Pregnancy	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Positive Regulation Of Catalytic Activity
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer formation of the beta-catenin:TCF transactivating complex Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer	G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		32 interactors: ASH2L CTNNB1 DBF4 ESR1 FANCD2 FOXN3 GFAP HDAC1 HDAC2 HIST1H3A HIST3H3 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF4 TP53 VIM	17 interactors: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		4221	10926
HPRD ID		00564	10371
Ensembl ID		ENSG00000133895	ENSG00000006634
Uniprot IDs		O00255 Q9GZQ5	B7Z8C6 Q9UBU7
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80	4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Chromosome Organization RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Response To Stress Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cell Differentiation Cellular Response To Stimulus Anatomical Structure Development Response To Stimulus Chromatin Organization Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Organelle Organization Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Differentiation	DNA Replication DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change DNA Conformation Change Cellular Response To DNA Damage Stimulus Chromosome Organization Cellular Metabolic Process Regulation Of DNA Replication DNA Repair Cellular Response To Stress Organelle Organization Regulation Of Nuclear Cell Cycle DNA Replication Signal Transduction In Response To DNA Damage Positive Regulation Of DNA-dependent DNA Replication Metabolic Process Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus DNA Damage Checkpoint Response To Epidermal Growth Factor Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of DNA Replication Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition
Tagcloud ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished
Tagcloud (Difference) ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished
Tagcloud (Intersection) ?