MEFV and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 26347139)
99

Data Source:
BioGRID (pull down)

		MEFV	GABARAPL2
Description		MEFV innate immunity regulator, pyrin	GABA type A receptor associated protein like 2
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Canonical Inflammasome Complex	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-1 Beta Production Response To Type II Interferon Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Response To Other Organism Pyroptotic Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptosome Complex Assembly	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Macroautophagy TBC/RABGAPs
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		4210	11345
HPRD ID		02012	16246
Ensembl ID		ENSG00000103313	ENSG00000034713
Uniprot IDs		D2DTW2 O15553	P60520
PDB IDs		2MPC 2WL1 4CG4 8C28 8C2Y 8C30 8SDJ	4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Mitophagy Macroautophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagy Vacuole Organization Response To Starvation Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Cellular Response To Starvation GABA Receptor Binding Response To Nutrient Levels Ubiquitin Protein Ligase Binding Microtubule Beta-tubulin Binding Organelle Assembly Cytoplasmic Vesicle Protein-containing Complex Organization Cytoplasm Cytosol Cellular Response To Stress Response To Stress Organelle Organization Catabolic Process Intra-Golgi Vesicle-mediated Transport Cellular Component Assembly Organelle Membrane Microtubule Binding CD27 Receptor Binding Myosin I Binding Endomembrane System Golgi Membrane Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Omegasome Membrane Inter-Golgi Cisterna Vesicle-mediated Transport Golgi Apparatus Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of NK T Cell Activation	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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