MEFV and PSTPIP1

Number of citations of the paper that reports this interaction (PMID 14595024)
55

Data Source:
HPRD (in vivo, two hybrid)

		MEFV	PSTPIP1
Gene Name		Mediterranean fever	proline-serine-threonine phosphatase interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytosol Microtubule Microtubule Associated Complex Lamellipodium	Stress Fiber Uropod Actomyosin Contractile Ring Cytosol Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Zinc Ion Binding	Actin Binding Protein Binding Protein Phosphatase Binding
	Biological Process	Inflammatory Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Cysteine-type Endopeptidase Activity	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: COG5 PSTPIP1 PYCARD SIVA1	29 interactors: ABL1 BUB3 CD2 CD2AP DNM2 FAM90A1 FASLG FBXL18 KHDRBS1 LSM4 MEFV MVP PCDHB14 PRPF31 PTPN12 PTPN18 RTP5 SDCBP SH2D4A SHBG SPG7 TRAF3IP3 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175
Entrez ID		4210	9051
HPRD ID		02012	05891
Ensembl ID		ENSG00000103313	ENSG00000140368
Uniprot IDs		D2DTW2 O15553	O43586
PDB IDs		2WL1	2DIL
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Mitochondrion Organization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrion Organization Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To Virus Vesicle-mediated Transport Activation-induced Cell Death Of T Cells Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Organelle Organization Inflammatory Response Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Secretion Negative Regulation Of Interferon-beta Production Regulation Of Interleukin-8 Secretion Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Pinocytosis Positive Regulation Of Defense Response To Virus By Host Immune System Process T Cell Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of T Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Rac GTPase Activity Positive Regulation Of Activated T Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Endocytosis Myeloid Dendritic Cell Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Regulation Of Defense Response To Virus By Host Response To Other Organism Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Membrane Tubulation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Nucleation Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Interferon-gamma Secretion Regulation Of Cytoskeleton Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Movement Actin Filament-based Process Mitotic Cell Cycle Process Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly Regulation Of Oxidoreductase Activity Regulation Of Cellular Component Organization Mitotic Cell Cycle Signaling Actin Polymerization Or Depolymerization Cytoskeleton Organization Cell Communication Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Rac Protein Signal Transduction Cell Projection Assembly Actin Filament Organization Mitotic Nuclear Division Nitric Oxide Metabolic Process Regulation Of Catalytic Activity Reactive Nitrogen Species Metabolic Process Endocytosis Cell Cycle Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endothelial Cell Apoptotic Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Substrate-dependent Cell Migration Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Nitric-oxide Synthase Activity
Tagcloud ?		aperture apnoea cephalometric collapsibility desaturation desaturations ent expiratory expiring fibroscopy fiv1 flows fvc hyoid hypopnoea inspiratory manoeuvre mef50 mifv mph muller osa palate pef pif shortest snorers spd spl	adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate
Tagcloud (Difference) ?		aperture apnoea cephalometric collapsibility desaturation desaturations ent expiratory expiring fibroscopy fiv1 flows fvc hyoid hypopnoea inspiratory manoeuvre mef50 mifv mph muller osa palate pef pif shortest snorers spd spl	adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate
Tagcloud (Intersection) ?