MEFV and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 26025129)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		MEFV	PSTPIP1
Description		MEFV innate immunity regulator, pyrin	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Canonical Inflammasome Complex	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-1 Beta Production Response To Type II Interferon Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Response To Other Organism Pyroptotic Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptosome Complex Assembly	Immune System Process Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Ankylosing spondylitis ( 30946743)	Hip circumference adjusted for BMI ( 34021172) Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		4210	9051
HPRD ID		02012	05891
Ensembl ID		ENSG00000103313	ENSG00000140368
Uniprot IDs		D2DTW2 O15553	A0A0S2Z5P3 J3KPG6 O43586
PDB IDs		2MPC 2WL1 4CG4 8C28 8C2Y 8C30 8SDJ	2DIL 7AAL 7AAM 7AAN
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Mitophagy Macroautophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagy Vacuole Organization Response To Starvation Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Cellular Response To Starvation GABA Receptor Binding Response To Nutrient Levels Ubiquitin Protein Ligase Binding Microtubule Beta-tubulin Binding Organelle Assembly Cytoplasmic Vesicle Protein-containing Complex Organization Cytoplasm Cytosol Cellular Response To Stress Response To Stress Organelle Organization Catabolic Process Intra-Golgi Vesicle-mediated Transport Cellular Component Assembly Organelle Membrane Microtubule Binding CD27 Receptor Binding Myosin I Binding Endomembrane System Golgi Membrane Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Omegasome Membrane Inter-Golgi Cisterna Vesicle-mediated Transport Golgi Apparatus Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of NK T Cell Activation	Actin Filament Polymerization Protein Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization SH3 Domain Binding Negative Regulation Of Membrane Tubulation Protein Binding Regulation Of Plasma Membrane Organization MRNA Processing RNA Splicing MRNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Spliceosomal Tri-snRNP Complex Regulation Of Double-strand Break Repair Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Lamellipodium Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Podosome Regulation Of Vitamin D Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Spliceosomal Complex Actin Cytoskeleton Ruffle SCAR Complex
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