MEFV and COG5

Number of citations of the paper that reports this interaction (PubMedID 10782044)
0

Data Source:
HPRD (two hybrid)

		MEFV	COG5
Description		MEFV innate immunity regulator, pyrin	component of oligomeric golgi complex 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Canonical Inflammasome Complex	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-1 Beta Production Response To Type II Interferon Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Response To Other Organism Pyroptotic Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptosome Complex Assembly	Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Inter-Golgi Cisterna Vesicle-mediated Transport Glycosylation
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 29892015) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Macular thickness ( 30535121) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Osteoarthritis ( 20112360) Pulse pressure ( 30578418 30224653) Serum alkaline phosphatase levels ( 33339817 33547301) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	5 interacting genes: APC COG4 COG7 MEFV RAC1
Entrez ID		4210	10466
HPRD ID		02012	08436
Ensembl ID		ENSG00000103313	ENSG00000164597
Uniprot IDs		D2DTW2 O15553	A0AAA9X096 A0AAA9X2X8 Q9UP83
PDB IDs		2MPC 2WL1 4CG4 8C28 8C2Y 8C30 8SDJ
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Mitophagy Macroautophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagy Vacuole Organization Response To Starvation Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Cellular Response To Starvation GABA Receptor Binding Response To Nutrient Levels Ubiquitin Protein Ligase Binding Microtubule Beta-tubulin Binding Organelle Assembly Cytoplasmic Vesicle Protein-containing Complex Organization Cytoplasm Cytosol Cellular Response To Stress Response To Stress Organelle Organization Catabolic Process Intra-Golgi Vesicle-mediated Transport Cellular Component Assembly Organelle Membrane Microtubule Binding CD27 Receptor Binding Myosin I Binding Endomembrane System Golgi Membrane Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Omegasome Membrane Inter-Golgi Cisterna Vesicle-mediated Transport Golgi Apparatus Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of NK T Cell Activation	Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Lamellipodium Intra-Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Pyroptosome Complex Assembly Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Golgi Organization Trans-Golgi Network Membrane Negative Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Glycosylation Cell-cell Junction Organization Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Regulation Of Cell Projection Assembly Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Regulation Of Microtubule-based Process Leading Edge Membrane Wnt Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Centrosome Kinocilium Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Neuron Maturation Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Thioesterase Binding Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Vesicle-mediated Transport Golgi Vesicle Transport Wnt Signalosome Positive Regulation Of Pseudopodium Assembly Beta-catenin Destruction Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?