MEFV and COG5

Number of citations of the paper that reports this interaction (PMID 10782044)
1

Data Source:
HPRD (two hybrid)

		MEFV	COG5
Gene Name		Mediterranean fever	component of oligomeric golgi complex 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytosol Microtubule Microtubule Associated Complex Lamellipodium	Golgi Membrane Nucleoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex
	Molecular Function	Actin Binding Zinc Ion Binding	Molecular_function Protein Binding
	Biological Process	Inflammatory Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Cysteine-type Endopeptidase Activity	Intra-Golgi Vesicle-mediated Transport Protein Transport
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS			Osteoarthritis ( 20112360)
Protein-Protein Interactions		4 interactors: COG5 PSTPIP1 PYCARD SIVA1	5 interactors: APC COG4 COG7 MEFV RAC1
Entrez ID		4210	10466
HPRD ID		02012	08436
Ensembl ID		ENSG00000103313	ENSG00000164597
Uniprot IDs		D2DTW2 O15553	Q9UP83
PDB IDs		2WL1
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Mitochondrion Organization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrion Organization Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To Virus Vesicle-mediated Transport Activation-induced Cell Death Of T Cells Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Organelle Organization Inflammatory Response Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Secretion Negative Regulation Of Interferon-beta Production Regulation Of Interleukin-8 Secretion Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Pinocytosis Positive Regulation Of Defense Response To Virus By Host Immune System Process T Cell Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of T Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Rac GTPase Activity Positive Regulation Of Activated T Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Endocytosis Myeloid Dendritic Cell Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Regulation Of Defense Response To Virus By Host Response To Other Organism Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Golgi Vesicle Prefusion Complex Stabilization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Complex Assembly Regulation Of Organ Morphogenesis Engulfment Of Apoptotic Cell Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Cytokine Production Protein Complex Assembly Cell-cell Junction Organization Mast Cell Chemotaxis Negative Regulation Of Odontogenesis Epidermis Development Golgi Vesicle Transport Positive Regulation Of Protein Metabolic Process Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Projection Organization Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Migration Regulation Of Protein Complex Assembly Olfactory Bulb Interneuron Development Positive Regulation Of Cell Motility Cellular Protein Complex Assembly Positive Regulation Of Cellular Component Movement Vesicle-mediated Transport Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Adhesion Regulation Of Respiratory Burst Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Auditory Receptor Cell Morphogenesis Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Organelle Organization Phagocytosis, Engulfment Inflammatory Response Olfactory Bulb Interneuron Differentiation Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Lamellipodium Assembly Endomembrane System Organization Auditory Receptor Cell Development Dopaminergic Neuron Differentiation
Tagcloud ?		aperture apnoea cephalometric collapsibility desaturation desaturations ent expiratory expiring fibroscopy fiv1 flows fvc hyoid hypopnoea inspiratory manoeuvre mef50 mifv mph muller osa palate pef pif shortest snorers spd spl	a2bp1 bcap29 carriage dentists dio2 dip dus4l dvwa esr1 finnish gdf5 hfe oa occupationally pard3b ptgs2 roa rs10953541 rs179945 rs1800470 rs3757713 rs716508 rs9340799 saw snpstats tbgf1 teachers tgfb1 trib1
Tagcloud (Difference) ?		aperture apnoea cephalometric collapsibility desaturation desaturations ent expiratory expiring fibroscopy fiv1 flows fvc hyoid hypopnoea inspiratory manoeuvre mef50 mifv mph muller osa palate pef pif shortest snorers spd spl	a2bp1 bcap29 carriage dentists dio2 dip dus4l dvwa esr1 finnish gdf5 hfe oa occupationally pard3b ptgs2 roa rs10953541 rs179945 rs1800470 rs3757713 rs716508 rs9340799 saw snpstats tbgf1 teachers tgfb1 trib1
Tagcloud (Intersection) ?