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MEFV
Gene Name
Mediterranean fever
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Microtubule
Microtubule Associated Complex
Lamellipodium
Molecular Function
Actin Binding
Zinc Ion Binding
Biological Process
Inflammatory Response
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Innate Immune Response
Negative Regulation Of Inflammatory Response
Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production
Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways
The NLRP3 inflammasome
Inflammasomes
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions
4 interactors:
COG5
PSTPIP1
PYCARD
SIVA1
Entrez ID
4210
HPRD ID
02012
Ensembl ID
ENSG00000103313
Uniprot IDs
D2DTW2
O15553
PDB IDs
2WL1
Enriched GO Terms of Interacting Partners
?
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Mitochondrion Organization
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Myeloid Dendritic Cell Activation Involved In Immune Response
Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Intrinsic Apoptotic Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Response To Virus
Vesicle-mediated Transport
Activation-induced Cell Death Of T Cells
Macropinocytosis
Positive Regulation Of Interleukin-6 Secretion
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Apoptotic Signaling Pathway
Positive Regulation Of Interleukin-8 Secretion
Positive Regulation Of Chemokine Secretion
Positive Regulation Of Organelle Organization
Inflammatory Response
Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Secretion
Negative Regulation Of Interferon-beta Production
Regulation Of Interleukin-8 Secretion
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pinocytosis
Positive Regulation Of Defense Response To Virus By Host
Immune System Process
T Cell Apoptotic Process
Positive Regulation Of T Cell Migration
Positive Regulation Of Interleukin-1 Beta Secretion
Regulation Of Interleukin-10 Secretion
Positive Regulation Of Interleukin-1 Secretion
Regulation Of T Cell Migration
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Rac GTPase Activity
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Interleukin-1 Beta Secretion
Positive Regulation Of Cell Death
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Endocytosis
Myeloid Dendritic Cell Activation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Regulation Of Defense Response To Virus By Host
Response To Other Organism
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Tagcloud
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aperture
apnoea
cephalometric
collapsibility
desaturation
desaturations
ent
expiratory
expiring
fibroscopy
fiv1
flows
fvc
hyoid
hypopnoea
inspiratory
manoeuvre
mef50
mifv
mph
muller
osa
palate
pef
pif
shortest
snorers
spd
spl