MEFV and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 18330885)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MEFV	SIVA1
Description		MEFV innate immunity regulator, pyrin	SIVA1 apoptosis inducing factor
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Canonical Inflammasome Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-1 Beta Production Response To Type II Interferon Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Response To Other Organism Pyroptotic Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptosome Complex Assembly	Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Canonical NF-kappaB Signal Transduction Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	33 interacting genes: ABL2 APP AQP1 BCL2 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCBP1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446
Entrez ID		4210	10572
HPRD ID		02012	16124
Ensembl ID		ENSG00000103313	ENSG00000184990
Uniprot IDs		D2DTW2 O15553	O15304
PDB IDs		2MPC 2WL1 4CG4 8C28 8C2Y 8C30 8SDJ
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Mitophagy Macroautophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagy Vacuole Organization Response To Starvation Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Cellular Response To Starvation GABA Receptor Binding Response To Nutrient Levels Ubiquitin Protein Ligase Binding Microtubule Beta-tubulin Binding Organelle Assembly Cytoplasmic Vesicle Protein-containing Complex Organization Cytoplasm Cytosol Cellular Response To Stress Response To Stress Organelle Organization Catabolic Process Intra-Golgi Vesicle-mediated Transport Cellular Component Assembly Organelle Membrane Microtubule Binding CD27 Receptor Binding Myosin I Binding Endomembrane System Golgi Membrane Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Omegasome Membrane Inter-Golgi Cisterna Vesicle-mediated Transport Golgi Apparatus Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of NK T Cell Activation	Response To Hydrogen Peroxide Channel Inhibitor Activity Identical Protein Binding Response To Reactive Oxygen Species Dendritic Cell Apoptotic Process Response To Radiation Response To Light Stimulus Response To Metal Ion BH3 Domain Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Response To Oxidative Stress Channel Activity Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Transcription By RNA Polymerase II Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Cell Activation Regulation Of Primary Metabolic Process Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Response To UV Protein Polyubiquitination Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Leukocyte Apoptotic Process Ubiquitin Ligase Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Cellular Response To Hydrogen Peroxide Regulation Of B Cell Proliferation T Cell Activation Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Sodium Ion Transport Cellular Response To Radiation Negative Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Monoatomic Ion Transmembrane Transport
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