MCF2 and GNA13

Number of citations of the paper that reports this interaction (PubMedID 11062019)
0

Data Source:
HPRD (in vitro, in vivo)

		MCF2	GNA13
Description		MCF.2 cell line derived transforming sequence	G protein subunit alpha 13
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Dendrite Development Intracellular Signal Transduction Negative Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Leukemia Inhibitory Factor	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)
Interacting Genes		8 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG STUB1 TNK2	31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		4168	10672
HPRD ID		02406	05100
Ensembl ID		ENSG00000101977	ENSG00000120063
Uniprot IDs		B2R9S6 P10911	Q14344
PDB IDs			7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH
Enriched GO Terms of Interacting Partners?		Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Regulation Of Postsynapse Assembly Intracellular Signal Transduction Postsynapse Rho Protein Signal Transduction G Protein Activity Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Regulation Of Vascular Associated Smooth Muscle Contraction Secretory Granule Membrane GTP Binding Positive Regulation Of Protein Modification Process Focal Adhesion Regulation Of Cell Shape Regulation Of Postsynapse Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Binding Regulation Of Synapse Assembly Rac Protein Signal Transduction Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein-containing Complex Assembly Heterotrimeric G-protein Complex Telencephalon Cell Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Membrane Invagination Cortical Cytoskeleton Organization Regulation Of Cell Morphogenesis Regulation Of Fibroblast Migration Actin Filament Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Brush Border Membrane Ficolin-1-rich Granule Membrane Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Metabolic Process Regulation Of Focal Adhesion Assembly Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure	G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol
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