MC4R and ASIP

Number of citations of the paper that reports this interaction (PMID 9058374)
19

Data Source:
HPRD (in vitro)

		MC4R	ASIP
Gene Name		melanocortin 4 receptor	agouti signaling protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Membrane	Extracellular Space
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Insulin Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Positive Regulation Of Bone Resorption Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Genetic Imprinting
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain ( 22566560) Body mass index ( 22344221 23563607 19079260 19079261 23669352 18454148 20935630) HDL cholesterol ( 20686565) Height ( 20881960) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 20421936) Obesity and blood pressure ( 22013104) Urate levels ( 23263486) Waist circumference ( 19557197) Waist circumference and related phenotypes ( 18454146) Weight ( 19079260)	Breast cancer ( 22976474) Burning and freckling ( 18488028) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Melanoma ( 21983787) Red vs. non-red hair color ( 18488028) Skin sensitivity to sun ( 18488028) Tanning ( 23548203)
Protein-Protein Interactions		9 interactors: ADRBK1 AGRP ASIP ATRNL1 IL1RAP MC1R NPY POMC PRKACA	6 interactors: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		4160	434
HPRD ID		01116	02562
Ensembl ID		ENSG00000166603	ENSG00000101440
Uniprot IDs		P32245	P42127
PDB IDs		2IQP 2IQR 2IQS 2IQU 2IQV 2IQW	1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Cellular Response To Stimulus Regulation Of Feeding Behavior Positive Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Adult Behavior Regulation Of Appetite Secondary Metabolite Biosynthetic Process Regulation Of Behavior Regulation Of The Force Of Heart Contraction Response To Stimulus Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Blood Circulation Positive Regulation Of Phospholipase C Activity Response To Light Stimulus Pigment Biosynthetic Process Cellular Pigmentation Cell-cell Signaling Positive Regulation Of CAMP Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Regulation Of CAMP Biosynthetic Process Response To Radiation Single-organism Behavior Cellular Response To Light Stimulus Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of CAMP Metabolic Process Histone H3-T6 Phosphorylation	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Feeding Behavior Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Homoiothermy Regulation Of Blood Pressure Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Protein Kinase A Signaling UV-damage Excision Repair Establishment Of Endothelial Intestinal Barrier Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Response To Stimulus Regulation Of Grooming Behavior Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Rho GTPase Activity UV Protection Positive Regulation Of Bone Resorption Regulation Of Protein Kinase A Signaling Positive Regulation Of Rap GTPase Activity Regulation Of Protein Kinase C Signaling Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Negative Regulation Of Ras GTPase Activity Response To Radiation Regulation Of Rap GTPase Activity Secondary Metabolite Biosynthetic Process Intestinal Absorption Sodium Ion Homeostasis Temperature Homeostasis Regulation Of Rap Protein Signal Transduction
Tagcloud ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?