MC4R and MC1R

Number of citations of the paper that reports this interaction (PMID 12165561)
33

Data Source:
HPRD (in vivo, in vitro)

		MC4R	MC1R
Gene Name		melanocortin 4 receptor	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding
	Biological Process	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Insulin Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Positive Regulation Of Bone Resorption Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organismal Development UV Protection Positive Regulation Of Protein Kinase A Signaling Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Feeding Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain ( 22566560) Body mass index ( 22344221 23563607 19079260 19079261 23669352 18454148 20935630) HDL cholesterol ( 20686565) Height ( 20881960) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 20421936) Obesity and blood pressure ( 22013104) Urate levels ( 23263486) Waist circumference ( 19557197) Waist circumference and related phenotypes ( 18454146) Weight ( 19079260)	Basal cell carcinoma ( 21700618) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Melanoma ( 21983787 19578364) Non-melanoma skin cancer ( 23548203) Red vs non-red hair color ( 17952075) Skin sensitivity to sun ( 17952075) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518)
Protein-Protein Interactions		9 interactors: ADRBK1 AGRP ASIP ATRNL1 IL1RAP MC1R NPY POMC PRKACA	3 interactors: ASIP MC4R POMC
Entrez ID		4160	4157
HPRD ID		01116	01118
Ensembl ID		ENSG00000166603	ENSG00000258839
Uniprot IDs		P32245	Q01726 Q1JUL4
PDB IDs		2IQP 2IQR 2IQS 2IQU 2IQV 2IQW
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Cellular Response To Stimulus Regulation Of Feeding Behavior Positive Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Adult Behavior Regulation Of Appetite Secondary Metabolite Biosynthetic Process Regulation Of Behavior Regulation Of The Force Of Heart Contraction Response To Stimulus Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Blood Circulation Positive Regulation Of Phospholipase C Activity Response To Light Stimulus Pigment Biosynthetic Process Cellular Pigmentation Cell-cell Signaling Positive Regulation Of CAMP Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Regulation Of CAMP Biosynthetic Process Response To Radiation Single-organism Behavior Cellular Response To Light Stimulus Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of CAMP Metabolic Process Histone H3-T6 Phosphorylation	Generation Of Precursor Metabolites And Energy Cellular Pigmentation Feeding Behavior Cell-cell Signaling Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Hormone Levels Regulation Of Corticosterone Secretion Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior Response To Nutrient Levels Response To Extracellular Stimulus Adult Feeding Behavior Regulation Of Feeding Behavior Behavior Positive Regulation Of Bone Resorption Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Pigment Granule Organization Secondary Metabolite Biosynthetic Process Positive Regulation Of Tissue Remodeling Genetic Imprinting Regulation Of Bone Resorption Peptide Hormone Processing Melanosome Transport Pigment Granule Transport Response To Hormone Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Melanosome Localization Insulin Secretion Regulation Of Bone Remodeling G-protein Coupled Receptor Signaling Pathway Pigment Biosynthetic Process Positive Regulation Of CAMP Biosynthetic Process Peptide Hormone Secretion Regulation Of Tissue Remodeling Peptide Secretion Positive Regulation Of CAMP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Hormone Secretion Signal Transduction Regulation Of CAMP Biosynthetic Process
Tagcloud ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?