MC4R and NPY

Number of citations of the paper that reports this interaction (PMID 12015205)
1

Data Source:
HPRD (in vitro, in vivo)

		MC4R	NPY
Gene Name		melanocortin 4 receptor	neuropeptide Y
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cell Golgi Apparatus
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	G-protein Coupled Receptor Activity Receptor Binding Neuropeptide Hormone Activity Calcium Channel Regulator Activity Neuropeptide Y Receptor Binding
	Biological Process	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Insulin Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Positive Regulation Of Bone Resorption Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	Calcium Ion Transport Movement Of Cell Or Subcellular Component G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Digestion Behavior Feeding Behavior Blood Circulation Regulation Of Blood Pressure Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Regulation Of Appetite Positive Regulation Of Appetite
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain ( 22566560) Body mass index ( 22344221 23563607 19079260 19079261 23669352 18454148 20935630) HDL cholesterol ( 20686565) Height ( 20881960) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 20421936) Obesity and blood pressure ( 22013104) Urate levels ( 23263486) Waist circumference ( 19557197) Waist circumference and related phenotypes ( 18454146) Weight ( 19079260)	Periodontitis ( 23459936)
Protein-Protein Interactions		9 interactors: ADRBK1 AGRP ASIP ATRNL1 IL1RAP MC1R NPY POMC PRKACA	15 interactors: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1
Entrez ID		4160	4852
HPRD ID		01116	01214
Ensembl ID		ENSG00000166603	ENSG00000122585
Uniprot IDs		P32245	A4D158 P01303
PDB IDs		2IQP 2IQR 2IQS 2IQU 2IQV 2IQW	1QFA 1RON
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Cellular Response To Stimulus Regulation Of Feeding Behavior Positive Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Adult Behavior Regulation Of Appetite Secondary Metabolite Biosynthetic Process Regulation Of Behavior Regulation Of The Force Of Heart Contraction Response To Stimulus Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Blood Circulation Positive Regulation Of Phospholipase C Activity Response To Light Stimulus Pigment Biosynthetic Process Cellular Pigmentation Cell-cell Signaling Positive Regulation Of CAMP Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Regulation Of CAMP Biosynthetic Process Response To Radiation Single-organism Behavior Cellular Response To Light Stimulus Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of CAMP Metabolic Process Histone H3-T6 Phosphorylation	Neuropeptide Signaling Pathway Feeding Behavior Cell-cell Signaling Synaptic Transmission G-protein Coupled Receptor Signaling Pathway Behavior Digestion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Transport Negative Regulation Of Secretion Negative Regulation Of Feeding Behavior Outflow Tract Morphogenesis Peptide Hormone Secretion Peptide Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Hormone Secretion Regulation Of CAMP Biosynthetic Process Hormone Transport Cell Surface Receptor Signaling Pathway Peptide Transport Signal Transduction Regulation Of Secretion Regulation Of CAMP Metabolic Process Regulation Of Feeding Behavior Cellular Response To Stimulus Cardiac Left Ventricle Morphogenesis Response To Stimulus Membrane Depolarization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Response To Food Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Positive Regulation Of Circadian Rhythm Amide Transport Regulation Of Appetite Cell Communication Multicellular Organismal Reproductive Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organism Reproduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Chemical Homeostasis Negative Regulation Of Secretion By Cell Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Negative Regulation Of Insulin Secretion Regulation Of Cellular Localization
Tagcloud ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally neuropeptide pflugers ramiprilat renovascular tubular
Tagcloud (Difference) ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally neuropeptide pflugers ramiprilat renovascular tubular
Tagcloud (Intersection) ?